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ABCG2 clia kit :: Human ABCG2 (ATP Binding Cassette Transporter G2) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2532868
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCG2 (ATP Binding Cassette Transporter G2), CLIA Kit

 Also Known As   

Human ABCG2 (ATP Binding Cassette Transporter G2) CLIA Kit

 Product Gene Name   

ABCG2 clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    138900
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant ABCG2. No significant cross-reactivity or interference between ABCG2 and analogues was observed.
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 Assay Type    Sandwich
 Detection Range    31.25-2000pg/mL
 Sensitivity    Min: 18.75pg/mL; Max: 2000pg/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ABCG2 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ABCG2 clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of ABCG2 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to ABCG2. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for ABCG2 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain ABCG2, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of ABCG2. You can calculate the concentration of ABCG2 in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ABCG2 clia kit    ABCG2 clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2532868. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ABCG2. It may not necessarily be applicable to this product.
 NCBI GI #    62526033
 NCBI GeneID    9429
 NCBI Accession #    NP_004818.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004827.2 [Other Products]
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 UniProt Secondary Accession #    O95374; Q4W5I3; Q53ZQ1; Q569L4; Q5YLG4; Q86V64; Q8IX16; Q96LD6; Q96TA8; A0A1W3; A8K1T5 [Other Products]
 UniProt Related Accession #    Q9UNQ0 [Other Products]
 Molecular Weight    67,453 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family G member 2 isoform 1
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
 NCBI Official Symbol    ABCG2 [Similar Products]
 NCBI Official Synonym Symbols   
MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; UAQTL1; EST157481
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family G member 2
 UniProt Protein Name    ATP-binding cassette sub-family G member 2
 UniProt Synonym Protein Names   
Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD_antigen: CD338
 Protein Family    ABC transporter G family
 UniProt Gene Name    ABCG2 [Similar Products]
 UniProt Synonym Gene Names    ABCP; BCRP; BCRP1; MXR [Similar Products]
 UniProt Entry Name    ABCG2_HUMAN
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 NCBI Summary for ABCG2    The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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 UniProt Comments for ABCG2    ABCG2: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123. Monomer or homodimer; disulfide-linked. Up-regulated in brain tumors. Highly expressed in placenta. Low expression in small intestine, liver and colon. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, iron; Transporter, ABC family

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: nucleoplasm; mitochondrial membrane; integral to membrane; plasma membrane; nucleus

Molecular Function: protein binding; protein homodimerization activity; transporter activity; ATPase activity, coupled to transmembrane movement of substances; heme transporter activity; ATP binding; xenobiotic-transporting ATPase activity

Biological Process: response to drug; heme transport; urate metabolic process; cellular iron ion homeostasis; transport; multidrug transport; xenobiotic transport; transmembrane transport

Disease: Blood Group, Junior System; Uric Acid Concentration, Serum, Quantitative Trait Locus 1
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 Research Articles on ABCG2    1. A high frequency of ABCG2 c.34G>A and c.421C>A variants was present in Chinese males.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ABCG2 clia kitPathways associated with ABCG2 clia kit
 Reference Product  PubMed Publications
 ABCC1 clia kit  >280 publications with ABCG2 and ABCC1
 ABCC2 clia kit  >232 publications with ABCG2 and ABCC2
 PTEN clia kit  >19 publications with ABCG2 and PTEN
 SLC22A1 clia kit  >19 publications with ABCG2 and SLC22A1
 HIF1A clia kit  >8 publications with ABCG2 and HIF1A
 ABL1 clia kit  >4 publications with ABCG2 and ABL1
 SLC22A2 clia kit  >3 publications with ABCG2 and SLC22A2
 ARNT clia kit  >2 publications with ABCG2 and ARNT
 SLC22A3 clia kit  >1 publications with ABCG2 and SLC22A3
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Abacavir Transmembrane Transport Pathway antibodies  Abacavir Transmembrane Transport Pathway Diagram
 Abacavir Transport And Metabolism Pathway antibodies  Abacavir Transport And Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Irinotecan Pathway antibodies  Irinotecan Pathway Diagram
Organs/Tissues associated with ABCG2 clia kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >424 publications with ABCG2 and Brain
 Liver Antibodies  >325 publications with ABCG2 and Liver
 Kidney Antibodies  >259 publications with ABCG2 and Kidney
 Lung Antibodies  >234 publications with ABCG2 and Lung
 Intestine Antibodies  >194 publications with ABCG2 and Intestine
 Placenta Antibodies  >126 publications with ABCG2 and Placenta
 Embryonic Tissue Antibodies  >121 publications with ABCG2 and Embryonic Tissue
 Vascular Antibodies  >113 publications with ABCG2 and Vascular
 Muscle Antibodies  >66 publications with ABCG2 and Muscle
 Prostate Antibodies  >57 publications with ABCG2 and Prostate
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