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ACE clia kit :: Human ACE (Angiotensin I Converting Enzyme) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2533276
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
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 Product Name   

ACE (Angiotensin I Converting Enzyme), CLIA Kit

 Also Known As   

Human ACE (Angiotensin I Converting Enzyme) CLIA Kit

 Product Synonym Names    ACE1; CD143; DCP; DCP1; ICH; MVCD3
 Product Gene Name   

ACE clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    106180
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant ACE. No significant cross-reactivity or interference between ACE and analogues was observed.
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 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL; Max: 10ng/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACE clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACE clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of ACE concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to ACE. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for ACE and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain ACE, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of ACE. You can calculate the concentration of ACE in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ACE clia kit    ACE clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2533276. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ACE. It may not necessarily be applicable to this product.
 NCBI GI #    76057114
 NCBI GeneID    1636
 NCBI Accession #    ABA39229.1 [Other Products]
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 UniProt Secondary Accession #    P22966; Q53YX9; Q59GY8; Q7M4L4; B0LPF0; B4DXI3; E7EU16 [Other Products]
 UniProt Related Accession #    P12821 [Other Products]
 Molecular Weight    78,694 Da
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 NCBI Official Full Name    angiotensin I converting enzyme, partial
 NCBI Official Synonym Full Names    angiotensin I converting enzyme
 NCBI Official Symbol    ACE [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    angiotensin-converting enzyme
 UniProt Protein Name    Angiotensin-converting enzyme
 UniProt Synonym Protein Names   
Dipeptidyl carboxypeptidase I; Kininase II; CD_antigen: CD143
 Protein Family    Acetylcholinesterase
 UniProt Gene Name    ACE [Similar Products]
 UniProt Synonym Gene Names    DCP; DCP1; ACE [Similar Products]
 UniProt Entry Name    ACE_HUMAN
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 NCBI Summary for ACE    This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
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 UniProt Comments for ACE    ACE: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. Genetic variations in ACE may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in ACE are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Genetic variations in ACE are associated with susceptibility to microvascular complications of diabetes type 3 (MVCD3). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in ACE are a cause of susceptibility to intracerebral hemorrhage (ICH). A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the peptidase M2 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Membrane protein, integral; EC

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; lysosome; integral to membrane; extracellular region; plasma membrane; endosome; external side of plasma membrane

Molecular Function: tripeptidyl-peptidase activity; peptidyl-dipeptidase activity; metallopeptidase activity; zinc ion binding; carboxypeptidase activity; mitogen-activated protein kinase kinase binding; drug binding; actin binding; protein binding; bradykinin receptor binding; endopeptidase activity; exopeptidase activity; mitogen-activated protein kinase binding; chloride ion binding

Biological Process: mononuclear cell proliferation; regulation of vasodilation; neutrophil mediated immunity; angiotensin mediated regulation of renal output; regulation of angiotensin metabolic process; arachidonic acid secretion; angiotensin maturation; regulation of systemic arterial blood pressure by renin-angiotensin; antigen processing and presentation of peptide antigen via MHC class I; regulation of smooth muscle cell migration; cellular protein metabolic process; heart contraction; regulation of blood pressure; regulation of vasoconstriction; peptide catabolic process; beta-amyloid metabolic process; angiotensin catabolic process in blood; blood vessel remodeling; hormone catabolic process; spermatogenesis; kidney development

Disease: Renal Tubular Dysgenesis; Microvascular Complications Of Diabetes, Susceptibility To, 3; Alzheimer Disease; Hemorrhage, Intracerebral, Susceptibility To
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 Research Articles on ACE    1. Angiotensin converting enzyme gene polymorphisms is associated with the risk of lung cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACE clia kitPathways associated with ACE clia kit
 Reference Product  PubMed Publications
 ACE2 clia kit  >546 publications with ACE and ACE2
 AGT clia kit  >479 publications with ACE and AGT
 BDKRB2 clia kit  >337 publications with ACE and BDKRB2
 NOS3 clia kit  >166 publications with ACE and NOS3
 REN clia kit  >157 publications with ACE and REN
 TFPI clia kit  >10 publications with ACE and TFPI
 ATP6AP2 clia kit  >10 publications with ACE and ATP6AP2
 MDK clia kit  >3 publications with ACE and MDK
 KNG1 clia kit  >1 publications with ACE and KNG1
 SOD3 clia kit  >1 publications with ACE and SOD3
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin Secretion Pathway antibodies  Renin Secretion Pathway Diagram
 Renin Secretion Pathway antibodies  Renin Secretion Pathway Diagram
Organs/Tissues associated with ACE clia kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12578 publications with ACE and Blood
 Heart Antibodies  >8524 publications with ACE and Heart
 Vascular Antibodies  >4698 publications with ACE and Vascular
 Kidney Antibodies  >4375 publications with ACE and Kidney
 Muscle Antibodies  >2242 publications with ACE and Muscle
 Lung Antibodies  >1635 publications with ACE and Lung
 Brain Antibodies  >1379 publications with ACE and Brain
 Intestine Antibodies  >287 publications with ACE and Intestine
 Eye Antibodies  >247 publications with ACE and Eye
 Testis Antibodies  >229 publications with ACE and Testis
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