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ACE2 clia kit :: Human ACE2 (Angiotensin I Converting Enzyme 2) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2530985
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACE2 (Angiotensin I Converting Enzyme 2), CLIA Kit

 Also Known As   

Human ACE2 (Angiotensin I Converting Enzyme 2) CLIA Kit

 Product Synonym Names    ACEH; ACEII
 Product Gene Name   

ACE2 clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    300335
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant ACE2. No significant cross-reactivity or interference between ACE2 and analogues was observed.
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 Assay Type    Sandwich
 Detection Range    78.125-5000pg/mL
 Sensitivity    Min: 46.875pg/mL; Max: 5000pg/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACE2 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACE2 clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of ACE2 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to ACE2. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for ACE2 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain ACE2, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of ACE2. You can calculate the concentration of ACE2 in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ACE2 clia kit    ACE2 clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2530985. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ACE2. It may not necessarily be applicable to this product.
 NCBI GI #    254546346
 NCBI GeneID    59272
 NCBI Accession #    ACT66268.1 [Other Products]
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 UniProt Secondary Accession #    Q6UWP0; Q86WT0; Q9NRA7; Q9UFZ6; C7ECU1 [Other Products]
 UniProt Related Accession #    Q9BYF1 [Other Products]
 Molecular Weight    63,912 Da
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 NCBI Official Full Name    angiotensin I converting enzyme 2
 NCBI Official Synonym Full Names    angiotensin I converting enzyme 2
 NCBI Official Symbol    ACE2 [Similar Products]
 NCBI Official Synonym Symbols   
ACEH
[Similar Products]
 NCBI Protein Information    angiotensin-converting enzyme 2
 UniProt Protein Name    Angiotensin-converting enzyme 2
 UniProt Synonym Protein Names   
ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH
 Protein Family    Angiotensin-converting enzyme
 UniProt Gene Name    ACE2 [Similar Products]
 UniProt Synonym Gene Names    ACEH [Similar Products]
 UniProt Entry Name    ACE2_HUMAN
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 NCBI Summary for ACE2    The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACE2    ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.17.23; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: extracellular space; cell surface; cytoplasm; extracellular region; plasma membrane; integral to membrane; lipid raft

Molecular Function: peptidyl-dipeptidase activity; viral receptor activity; protein binding; carboxypeptidase activity; zinc ion binding; metallopeptidase activity; endopeptidase activity; glycoprotein binding

Biological Process: virion attachment, binding of host cell surface receptor; entry of virus into host cell; regulation of vasodilation; angiotensin maturation; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of cell proliferation; regulation of cytokine production; tryptophan transport; cellular protein metabolic process; regulation of vasoconstriction; angiotensin catabolic process in blood; regulation of inflammatory response; receptor biosynthetic process; angiotensin mediated drinking behavior
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 Research Articles on ACE2    1. There is no clear association between ACE2 gene A9570G polymorphisms and childhood primary nephrotic syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACE2 clia kitPathways associated with ACE2 clia kit
 Reference Product  PubMed Publications
 ACE clia kit  >546 publications with ACE2 and ACE
 AGT clia kit  >31 publications with ACE2 and AGT
 REN clia kit  >23 publications with ACE2 and REN
 AGTR1 clia kit  >16 publications with ACE2 and AGTR1
 ATP6AP2 clia kit  >9 publications with ACE2 and ATP6AP2
 CMA1 clia kit  >1 publications with ACE2 and CMA1
 MME clia kit  >1 publications with ACE2 and MME
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Organs/Tissues associated with ACE2 clia kit
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >287 publications with ACE2 and Kidney
 Muscle Antibodies  >160 publications with ACE2 and Muscle
 Brain Antibodies  >90 publications with ACE2 and Brain
 Intestine Antibodies  >23 publications with ACE2 and Intestine
 Placenta Antibodies  >17 publications with ACE2 and Placenta
 Testis Antibodies  >12 publications with ACE2 and Testis
 Eye Antibodies  >11 publications with ACE2 and Eye
 Mixed Antibodies  >9 publications with ACE2 and Mixed
 Stomach Antibodies  >4 publications with ACE2 and Stomach
 Mouth Antibodies  >2 publications with ACE2 and Mouth
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