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ACTa1 clia kit :: Human ACTalpha1 (Actin Alpha 1, Skeletal Muscle) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2532453
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTalpha1 (Actin Alpha 1, Skeletal Muscle) (ACTa1), CLIA Kit

 Also Known As   

Human ACTalpha1 (Actin Alpha 1, Skeletal Muscle) CLIA Kit

 Product Synonym Names    ACTA1; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3; Human ACTa1 (Actin Alpha 1, Skeletal Muscle) CLIA Kit; Human ACTa1
 Product Gene Name   

ACTa1 clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    102610
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant ACTalpha1. No significant cross-reactivity or interference between ACTalpha1 and analogues was observed.
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 Assay Type    Sandwich
 Detection Range    62.5-4000pg/mL
 Sensitivity    Min: 37.5pg/mL; Max: 4000pg/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACTa1 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACTa1 clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of ACTalpha1 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to ACTalpha1. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for ACTalpha1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain ACTalpha1, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of ACTalpha1. You can calculate the concentration of ACTalpha1 in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ACTa1 clia kit    ACTa1 clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2532453. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ACTa1. It may not necessarily be applicable to this product.
 NCBI GI #    30908859
 NCBI GeneID    58
 NCBI Accession #    AAP37280.1 [Other Products]
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 UniProt Secondary Accession #    P02568; P99020; Q5T8M9 [Other Products]
 UniProt Related Accession #    P68133 [Other Products]
 Molecular Weight    42,051 Da
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 NCBI Official Full Name    actin alpha 1 skeletal muscle protein
 NCBI Official Synonym Full Names    actin, alpha 1, skeletal muscle
 NCBI Official Symbol    ACTA1 [Similar Products]
 NCBI Official Synonym Symbols   
ACTA; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM
[Similar Products]
 NCBI Protein Information    actin, alpha skeletal muscle
 UniProt Protein Name    Actin, alpha skeletal muscle
 UniProt Synonym Protein Names   
Alpha-actin-1
 UniProt Gene Name    ACTA1 [Similar Products]
 UniProt Synonym Gene Names    ACTA [Similar Products]
 UniProt Entry Name    ACTS_HUMAN
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 NCBI Summary for ACTa1    The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACTa1    ACTA1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family.

Protein type: Contractile; Cell development/differentiation; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: extracellular space; sarcomere; lamellipodium; stress fiber; actin filament; cytosol; striated muscle thin filament; actin cytoskeleton; filopodium

Molecular Function: protein binding; myosin binding; structural constituent of cytoskeleton; ADP binding; ATP binding

Biological Process: skeletal muscle fiber adaptation; muscle contraction; response to mechanical stimulus; response to steroid hormone stimulus; muscle thin filament assembly; response to extracellular stimulus; response to lithium ion; skeletal muscle fiber development; cell growth; muscle filament sliding

Disease: Nemaline Myopathy 3; Myopathy, Congenital, With Fiber-type Disproportion
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 Research Articles on ACTa1    1. New scapuloperoneal phenotype associated with an ACTA1 mutation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACTa1 clia kitPathways associated with ACTa1 clia kit
 Reference Product  PubMed Publications
 GSN clia kit  >2 publications with ACTa1 and GSN
 DMD clia kit  >1 publications with ACTa1 and DMD
 Products by Pathway  Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Hypothetical Network For Drug Addiction Pathway antibodies  Hypothetical Network For Drug Addiction Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 RhoA Signaling Pathway antibodies  RhoA Signaling Pathway Diagram
 Signaling Events Mediated By Focal Adhesion Kinase Pathway antibodies  Signaling Events Mediated By Focal Adhesion Kinase Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Organs/Tissues associated with ACTa1 clia kit
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >139 publications with ACTa1 and Muscle
 Heart Antibodies  >33 publications with ACTa1 and Heart
 Brain Antibodies  >14 publications with ACTa1 and Brain
 Embryonic Tissue Antibodies  >7 publications with ACTa1 and Embryonic Tissue
 Nerve Antibodies  >6 publications with ACTa1 and Nerve
 Bone Antibodies  >5 publications with ACTa1 and Bone
 Lung Antibodies  >5 publications with ACTa1 and Lung
 Vascular Antibodies  >3 publications with ACTa1 and Vascular
 Adipose Tissue Antibodies  >2 publications with ACTa1 and Adipose Tissue
 Eye Antibodies  >2 publications with ACTa1 and Eye
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