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ACTa2 clia kit :: Human ACTalpha2 (Actin Alpha 2, Smooth Muscle) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2532519
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTalpha2 (Actin Alpha 2, Smooth Muscle) (ACTa2), CLIA Kit

 Also Known As   

Human ACTalpha2 (Actin Alpha 2, Smooth Muscle) CLIA Kit

 Product Synonym Names    ACTA2; AAT6; ACTSA; MYMY5; Human ACTa2 (Actin Alpha 2, Smooth Muscle) CLIA Kit; Human ACTa2
 Product Gene Name   

ACTa2 clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    102620
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant ACTalpha2. No significant cross-reactivity or interference between ACTalpha2 and analogues was observed.
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 Assay Type    Sandwich
 Detection Range    0.625-40ng/mL
 Sensitivity    Min: 0.375ng/mL; Max: 40ng/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACTa2 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACTa2 clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of ACTalpha2 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to ACTalpha2. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for ACTalpha2 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain ACTalpha2, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of ACTalpha2. You can calculate the concentration of ACTalpha2 in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ACTa2 clia kit    ACTa2 clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2532519. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ACTa2. It may not necessarily be applicable to this product.
 NCBI GI #    119570540
 NCBI GeneID    59
 NCBI Accession #    EAW50155.1 [Other Products]
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 UniProt Secondary Accession #    P03996; P04108; Q6FI19; B2R8A4 [Other Products]
 UniProt Related Accession #    P62736 [Other Products]
 Molecular Weight    42,009 Da
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 NCBI Official Full Name    actin, alpha 2, smooth muscle, aorta, isoform CRA_a
 NCBI Official Synonym Full Names    actin, alpha 2, smooth muscle, aorta
 NCBI Official Symbol    ACTA2 [Similar Products]
 NCBI Official Synonym Symbols   
AAT6; ACTSA; MYMY5
[Similar Products]
 NCBI Protein Information    actin, aortic smooth muscle
 UniProt Protein Name    Actin, aortic smooth muscle
 UniProt Synonym Protein Names   
Alpha-actin-2; Cell growth-inhibiting gene 46 protein
 Protein Family    Actin
 UniProt Gene Name    ACTA2 [Similar Products]
 UniProt Synonym Gene Names    ACTSA; ACTVS [Similar Products]
 UniProt Entry Name    ACTA_HUMAN
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 NCBI Summary for ACTa2    The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
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 UniProt Comments for ACTa2    ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Contractile

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: extracellular space; protein complex; smooth muscle contractile fiber; lamellipodium; cytoplasm; cytosol; filopodium; actin cytoskeleton

Molecular Function: protein kinase binding; ATP binding

Biological Process: muscle contraction; response to virus; regulation of blood pressure; vascular smooth muscle contraction

Disease: Multisystemic Smooth Muscle Dysfunction Syndrome; Moyamoya Disease 5; Aortic Aneurysm, Familial Thoracic 6
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 Research Articles on ACTa2    1. The immunohistochemical expression of E-cadherin and alpha-smooth muscle actin (alpha-SMA) in 15 cases of pleomorphic adenoma of salivary glands, were investigated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACTa2 clia kitPathways associated with ACTa2 clia kit
 Reference Product  PubMed Publications
 MYH11 clia kit  >34 publications with ACTa2 and MYH11
 SRF clia kit  >14 publications with ACTa2 and SRF
 TPM3 clia kit  >6 publications with ACTa2 and TPM3
 MYOCD clia kit  >6 publications with ACTa2 and MYOCD
 TPM2 clia kit  >1 publications with ACTa2 and TPM2
 TPM1 clia kit  >1 publications with ACTa2 and TPM1
 UBC clia kit  >1 publications with ACTa2 and UBC
 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
Organs/Tissues associated with ACTa2 clia kit
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >727 publications with ACTa2 and Muscle
 Vascular Antibodies  >230 publications with ACTa2 and Vascular
 Blood Antibodies  >168 publications with ACTa2 and Blood
 Lung Antibodies  >124 publications with ACTa2 and Lung
 Eye Antibodies  >121 publications with ACTa2 and Eye
 Liver Antibodies  >111 publications with ACTa2 and Liver
 Connective Tissue Antibodies  >110 publications with ACTa2 and Connective Tissue
 Kidney Antibodies  >89 publications with ACTa2 and Kidney
 Skin Antibodies  >78 publications with ACTa2 and Skin
 Heart Antibodies  >62 publications with ACTa2 and Heart
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