NP_057069.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,416 Da
NCBI Official Full Name
angiopoietin-4
NCBI Official Synonym Full Names
angiopoietin 4
NCBI Protein Information
angiopoietin-4
UniProt Protein Name
Angiopoietin-4
UniProt Synonym Protein Names
Angiopoietin-3; ANG-3
UniProt Synonym Gene Names
UniProt Entry Name
ANGP4_HUMAN
NCBI Summary for ANGPT4
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
UniProt Comments for ANGPT4
ANGPT4: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: extracellular space; extracellular region
Molecular Function: transmembrane receptor protein tyrosine kinase activator activity; receptor tyrosine kinase binding
Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of angiogenesis; Notch signaling pathway; positive regulation of angiogenesis; transmembrane receptor protein tyrosine kinase activation (dimerization); endothelial cell proliferation; positive regulation of blood vessel endothelial cell migration; angiogenesis; blood coagulation; negative regulation of blood vessel endothelial cell migration; leukocyte migration; negative regulation of apoptosis
Research Articles on ANGPT4
Precautions
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Products associated with ANGPT4 clia kit
Pathways associated with ANGPT4 clia kit
Organs/Tissues associated with ANGPT4 clia kit
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