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BMP4 clia kit :: Goat Bone Morphogenetic Protein 4 (BMP4) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2000952 (SPECIAL PROMOTION: Get FREE Starbucks gift card ($5 for 48-Wells-Kit or $10 for 96-Wells-Kit. Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells  /  $345 +1 FREE 8GB USB
48-Strip-Wells  /  $685 +1 FREE 8GB USB
96-Strip-Wells  /  $945 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,865 +4 FREE 8GB USB
10x96-Strip-Wells  /  $6,925 +8 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bone Morphogenetic Protein 4 (BMP4), CLIA Kit

 Also Known As   

Bone Morphogenetic Protein 4 (BMP4) CLIA Kit

 Product Synonym Names    BMP2B; BMP2-B; BMP2B1; ZYME; DVR4; Bone morphogenetic protein 2B
 Product Gene Name   

BMP4 clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    112262
 3D Structure    ModBase 3D Structure for P12644
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 Species Reactivity    Goat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Bone Morphogenetic Protein 4 (BMP4).
No significant cross-reactivity or interference between Bone Morphogenetic Protein 4 (BMP4) and analogues was observed.
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 Assay Type    Double-antibody Sandwich
 Samples    Serum, Plasma, Tissue homogenates and Other Biological Fluids
 Detection Range    27.4-20,000pg/mL
 Sensitivity    < 12.3pg/mL
 Application    Chemiluminescent immunoassay for Antigen Detection.
 Intra-assay Precision (Precision within an assay)    3 samples with low, middle and high level Bone Morphogenetic Protein 4 (BMP4) were tested 20 times on one plate, respectively.
 Inter-assay Precision (Precision between assays)    3 samples with low, middle and high level Bone Morphogenetic Protein 4 (BMP4) were tested on 3 different plates, 8 replicates in each plate.
 CV(%) =    SD/meanX100
 Intra-Assay    CV<10%
 Inter-Assay    CV<12%
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 Preparation and Storage    The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of BMP4 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BMP4 clia kit

   The microplate provided in this kit has been pre-coated with an antibody specific to Bone Morphogenetic Protein 4 (BMP4). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Bone Morphogenetic Protein 4 (BMP4). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then the mixture of substrate A and B is added to generate glow light emission kinetics. Upon plate development, the intensity of the emitted light is proportional to the Bone Morphogenetic Protein 4 (BMP4) level in the sample or standard.;
 Product Categories/Family for BMP4 clia kit    Developmental science; Bone metabolism
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 Typical Testing Data/Standard Curve (for reference only) of BMP4 clia kit    BMP4 clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2000952. Click to request current manual
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NCBI/Uniprot data below describe general gene information for BMP4. It may not necessarily be applicable to this product.
 NCBI GI #    1311542
 NCBI GeneID    652
 NCBI Accession #    BAA06410.1 [Other Products]
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 UniProt Primary Accession #    P12644 [Other Products]
 UniProt Secondary Accession #    Q9UM80 [Other Products]
 UniProt Related Accession #    P12644 [Other Products]
 Molecular Weight    46,555 Da
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 NCBI Official Full Name    bone morphogenetic protein 4
 NCBI Official Synonym Full Names    bone morphogenetic protein 4
 NCBI Official Symbol    BMP4 [Similar Products]
 NCBI Official Synonym Symbols   
ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein 4
 UniProt Protein Name    Bone morphogenetic protein 4
 UniProt Synonym Protein Names   
Bone morphogenetic protein 2B; BMP-2B
 Protein Family    Bone morphogenetic protein
 UniProt Gene Name    BMP4 [Similar Products]
 UniProt Synonym Gene Names    BMP2B; DVR4; BMP-4; BMP-2B [Similar Products]
 UniProt Entry Name    BMP4_HUMAN
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 NCBI Summary for BMP4    The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMP4    BMP4: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Homodimer; disulfide-linked. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with SOSTDC1. Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q22-q23

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; chemoattractant activity

Biological Process: negative regulation of MAP kinase activity; renal system process; extracellular matrix organization and biogenesis; macrophage differentiation; activation of MAPKK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; lymphoid progenitor cell differentiation; telencephalon regionalization; post-embryonic development; germ cell development; regulation of protein import into nucleus; BMP signaling pathway; positive regulation of endothelial cell differentiation; positive chemotaxis; erythrocyte differentiation; chondrocyte differentiation; mesonephros development; kidney development; endochondral ossification; regulation of odontogenesis of dentine-containing teeth; negative regulation of immature T cell proliferation in the thymus; positive regulation of cardiac muscle fiber development; specification of organ position; monocyte differentiation; neuron fate commitment; embryonic cranial skeleton morphogenesis; negative regulation of striated muscle development; branching morphogenesis of a tube; negative regulation of mitosis; positive regulation of epidermal cell differentiation; negative regulation of phosphorylation; hemopoietic progenitor cell differentiation; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of protein binding; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; cloacal septation; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; negative regulation of cell cycle; odontogenesis; smooth muscle development; negative regulation of cell proliferation; inner ear receptor cell differentiation; ureteric bud development; intermediate mesodermal cell differentiation; regulation of smooth muscle cell differentiation; positive regulation of BMP signaling pathway; dorsoventral neural tube patterning; negative regulation of epithelial cell proliferation; smoothened signaling pathway; common-partner SMAD protein phosphorylation; negative regulation of T cell differentiation in the thymus; positive regulation of bone mineralization; positive regulation of ossification; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of osteoblast differentiation; telencephalon development; blood vessel endothelial cell proliferation during sprouting angiogenesis; ureteric bud branching; pituitary gland development; regulation of cell fate commitment; neural tube closure; positive regulation of protein amino acid phosphorylation; positive regulation of neuron differentiation; negative regulation of myoblast differentiation; mesodermal cell fate determination; anterior/posterior axis specification

Disease: Orofacial Cleft 11; Microphthalmia, Syndromic 6
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 Research Articles on BMP4    1. the decrease in E-cadherin and/or increase in N-cadherin may be required for BMP4-induced migration and EMT.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMP4 clia kitPathways associated with BMP4 clia kit
 Reference Product  PubMed Publications
 SHH clia kit  >241 publications with BMP4 and SHH
 BMPR2 clia kit  >144 publications with BMP4 and BMPR2
 BMPR1A clia kit  >140 publications with BMP4 and BMPR1A
 SMAD5 clia kit  >75 publications with BMP4 and SMAD5
 BMPR1B clia kit  >34 publications with BMP4 and BMPR1B
 NOG clia kit  >18 publications with BMP4 and NOG
 SOSTDC1 clia kit  >6 publications with BMP4 and SOSTDC1
 FST clia kit  >4 publications with BMP4 and FST
 CHRD clia kit  >4 publications with BMP4 and CHRD
 CHRDL1 clia kit  >3 publications with BMP4 and CHRDL1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glypican 3 Network Pathway antibodies  Glypican 3 Network Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
Diseases associated with BMP4 clia kitOrgans/Tissues associated with BMP4 clia kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >232 publications with BMP4 and Neoplasms
 Cardiovascular Diseases Antibodies  >101 publications with BMP4 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >99 publications with BMP4 and Disease Models, Animal
 Nervous System Diseases Antibodies  >96 publications with BMP4 and Nervous System Diseases
 Heart Diseases Antibodies  >61 publications with BMP4 and Heart Diseases
 Hypertension Antibodies  >56 publications with BMP4 and Hypertension
 Brain Diseases Antibodies  >54 publications with BMP4 and Brain Diseases
 Inflammation Antibodies  >51 publications with BMP4 and Inflammation
 Lung Diseases Antibodies  >47 publications with BMP4 and Lung Diseases
 Adenocarcinoma Antibodies  >46 publications with BMP4 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2506 publications with BMP4 and Bone
 Embryonic Tissue Antibodies  >668 publications with BMP4 and Embryonic Tissue
 Brain Antibodies  >256 publications with BMP4 and Brain
 Vascular Antibodies  >237 publications with BMP4 and Vascular
 Heart Antibodies  >212 publications with BMP4 and Heart
 Mouth Antibodies  >168 publications with BMP4 and Mouth
 Connective Tissue Antibodies  >165 publications with BMP4 and Connective Tissue
 Eye Antibodies  >153 publications with BMP4 and Eye
 Lung Antibodies  >129 publications with BMP4 and Lung
 Skin Antibodies  >120 publications with BMP4 and Skin
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