AAQ89046.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
EG-VEGF
NCBI Official Synonym Full Names
prokineticin 1
NCBI Protein Information
prokineticin-1
UniProt Protein Name
Prokineticin-1
UniProt Synonym Protein Names
Endocrine-gland-derived vascular endothelial growth factor; EG-VEGF; Mambakine
UniProt Synonym Gene Names
UniProt Entry Name
PROK1_HUMAN
NCBI Summary for EG-VEGF
The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]
UniProt Comments for EG-VEGF
PROK1: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. Belongs to the AVIT (prokineticin) family.
Protein type: Cell cycle regulation; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p21
Cellular Component: extracellular region
Molecular Function: growth factor activity; G-protein-coupled receptor binding
Biological Process: circadian rhythm; activation of MAPK activity; positive regulation of cell division; positive regulation of cell proliferation; angiogenesis; regulation of angiogenesis
Research Articles on EG-VEGF
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Products associated with EG-VEGF clia kit
Pathways associated with EG-VEGF clia kit
Organs/Tissues associated with EG-VEGF clia kit
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