AFA26280.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
129,746 Da
NCBI Official Full Name
epidermal growth factor, partial
NCBI Official Synonym Full Names
epidermal growth factor
NCBI Official Synonym Symbols
NCBI Protein Information
pro-epidermal growth factor
UniProt Protein Name
Pro-epidermal growth factor
UniProt Synonym Protein Names
Epidermal growth factorAlternative name(s):Urogastrone
UniProt Synonym Gene Names
UniProt Entry Name
EGF_HUMAN
NCBI Summary for EGF
This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for EGF
EGF: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4); also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral; Hormone
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: extracellular region; extracellular space; integral to membrane; lysosomal membrane; plasma membrane; receptor complex
Molecular Function: calcium ion binding; epidermal growth factor receptor binding; growth factor activity; protein binding; transmembrane receptor protein tyrosine kinase activator activity; Wnt receptor activity; Wnt-protein binding
Biological Process: activation of MAPKK activity; angiogenesis; axon guidance; blood coagulation; branching morphogenesis of a tube; DNA replication; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of secretion; nerve growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; platelet activation; platelet degranulation; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor activity; positive regulation of granule cell precursor proliferation; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; STAT protein nuclear translocation; transmembrane receptor protein tyrosine kinase activation (dimerization); vascular endothelial growth factor receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Disease: Hypomagnesemia 4, Renal
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Products associated with EGF clia kit
Pathways associated with EGF clia kit
Organs/Tissues associated with EGF clia kit
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