NP_006024.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,362 Da
NCBI Official Full Name
endothelial lipase isoform 1
NCBI Official Synonym Full Names
lipase, endothelial
NCBI Protein Information
endothelial lipase
UniProt Protein Name
Endothelial lipase
UniProt Synonym Protein Names
Endothelial cell-derived lipase; EDL; EL
UniProt Synonym Gene Names
UniProt Entry Name
LIPE_HUMAN
NCBI Summary for EL
The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]
UniProt Comments for EL
LIPG: Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - glycerolipid; EC 3.1.1.3; Secreted, signal peptide; Phospholipase; Secreted
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: Golgi apparatus; extracellular space; cell surface; early endosome
Molecular Function: heparin binding; lipoprotein lipase activity; phospholipase A1 activity; phospholipase activity
Biological Process: cell proliferation; cholesterol homeostasis; reverse cholesterol transport; phospholipid catabolic process; regulation of lipoprotein metabolic process; lipid metabolic process; positive regulation of cholesterol transport; response to nutrient; phospholipid homeostasis
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Products associated with EL clia kit
Pathways associated with EL clia kit
Organs/Tissues associated with EL clia kit
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