NP_002299.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,321 Da
NCBI Official Full Name
galectin-9 isoform short
NCBI Official Synonym Full Names
lectin, galactoside-binding, soluble, 9
NCBI Protein Information
galectin-9
UniProt Protein Name
Galectin-9
UniProt Synonym Protein Names
Ecalectin; Tumor antigen HOM-HD-21
UniProt Synonym Gene Names
UniProt Entry Name
LEG9_HUMAN
NCBI Summary for GAL9
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GAL9
galectin-9: Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: extracellular space; cytoplasm; intracellular; nucleus
Molecular Function: signal transducer activity; enzyme binding; galactose binding; carbohydrate binding
Biological Process: negative regulation of chemokine production; maternal process involved in pregnancy; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of mast cell degranulation; negative regulation of activated T cell proliferation; negative regulation of natural killer cell mediated cytotoxicity; response to lipopolysaccharide; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; negative regulation of tumor necrosis factor production; female pregnancy; chemotaxis; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-4 production; positive regulation of virion penetration into host cell; natural killer cell tolerance induction; negative regulation of interferon-gamma production; inflammatory response; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
Research Articles on GAL9
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Products associated with GAL9 clia kit
Pathways associated with GAL9 clia kit
Organs/Tissues associated with GAL9 clia kit
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