AAB87062.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,414 Da
NCBI Official Full Name
glypican 3, partial
NCBI Official Synonym Full Names
glypican 3
NCBI Official Synonym Symbols
SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2 [Similar Products]
NCBI Protein Information
glypican-3
UniProt Protein Name
Glypican-3
UniProt Synonym Protein Names
GTR2-2; Intestinal protein OCI-5; MXR7
UniProt Synonym Gene Names
UniProt Entry Name
GPC3_HUMAN
NCBI Summary for GPC3
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
UniProt Comments for GPC3
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
Research Articles on GPC3
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Products associated with GPC3 clia kit
Pathways associated with GPC3 clia kit
Organs/Tissues associated with GPC3 clia kit
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