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LTA4H clia kit :: Human LTA4H (Leukotriene A4 Hydrolase) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2531121
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LTA4H (Leukotriene A4 Hydrolase), CLIA Kit

★Popular Item★
 Also Known As   

Human LTA4H (Leukotriene A4 Hydrolase) CLIA Kit

 Product Gene Name   

LTA4H clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    151570
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant LTA4H. No significant cross-reactivity or interference between LTA4H and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    62.5-4000pg/mL
 Sensitivity    37.5pg/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LTA4H clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LTA4H clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of LTA4H concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to LTA4H. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for LTA4H and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain LTA4H, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of LTA4H. You can calculate the concentration of LTA4H in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of LTA4H clia kit    LTA4H clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2531121. Click to request current manual
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NCBI/Uniprot data below describe general gene information for LTA4H. It may not necessarily be applicable to this product.
 NCBI GI #    976396
 NCBI GeneID    4048
 NCBI Accession #    AAA89077.1 [Other Products]
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 UniProt Secondary Accession #    Q6IAT6; Q9UCT7; B4DNQ9; F8VV40 [Other Products]
 UniProt Related Accession #    P09960 [Other Products]
 Molecular Weight    66,852 Da
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 NCBI Official Full Name    leukotriene A4 hydrolase
 NCBI Official Synonym Full Names    leukotriene A4 hydrolase
 NCBI Official Symbol    LTA4H [Similar Products]
 NCBI Protein Information    leukotriene A-4 hydrolase
 UniProt Protein Name    Leukotriene A-4 hydrolase
 UniProt Synonym Protein Names   
Leukotriene A(4) hydrolase
 Protein Family    Leukotriene A-4 hydrolase
 UniProt Gene Name    LTA4H [Similar Products]
 UniProt Synonym Gene Names    LTA4; LTA-4 hydrolase [Similar Products]
 UniProt Entry Name    LKHA4_HUMAN
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 NCBI Summary for LTA4H    The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
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 UniProt Comments for LTA4H    LTA4H: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Belongs to the peptidase M1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.3.2.6; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: peptidase activity; leukotriene-A4 hydrolase activity; zinc ion binding; epoxide hydrolase activity; aminopeptidase activity; peptide binding

Biological Process: leukotriene biosynthetic process; response to peptide hormone stimulus; response to zinc ion; peptide catabolic process; arachidonic acid metabolic process; leukotriene metabolic process; proteolysis; inflammatory response
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 Research Articles on LTA4H    1. The best proteinogenic amino acid recognized by LTA4H is arginine.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LTA4H clia kitPathways associated with LTA4H clia kit
 Reference Product  PubMed Publications
 ALOX5AP clia kit  >19 publications with LTA4H and ALOX5AP
 LTC4S clia kit  >17 publications with LTA4H and LTC4S
 LTB4R2 clia kit  >2 publications with LTA4H and LTB4R2
 PTGR1 clia kit  >1 publications with LTA4H and PTGR1
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway antibodies  Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway Diagram
 Leukotriene Biosynthesis Pathway antibodies  Leukotriene Biosynthesis Pathway Diagram
 Leukotriene Biosynthesis Pathway antibodies  Leukotriene Biosynthesis Pathway Diagram
Organs/Tissues associated with LTA4H clia kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with LTA4H and Blood
 Lung Antibodies  >17 publications with LTA4H and Lung
 Vascular Antibodies  >7 publications with LTA4H and Vascular
 Bone Antibodies  >5 publications with LTA4H and Bone
 Heart Antibodies  >5 publications with LTA4H and Heart
 Nerve Antibodies  >4 publications with LTA4H and Nerve
 Muscle Antibodies  >4 publications with LTA4H and Muscle
 Bone Marrow Antibodies  >4 publications with LTA4H and Bone Marrow
 Intestine Antibodies  >3 publications with LTA4H and Intestine
 Skin Antibodies  >2 publications with LTA4H and Skin
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