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MYBPC3 clia kit :: Human MYBPC3 (Myosin Binding Protein C, Cardiac) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2530553
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MYBPC3 (Myosin Binding Protein C, Cardiac), CLIA Kit

★Popular Item★
 Also Known As   

Human MYBPC3 (Myosin Binding Protein C, Cardiac) CLIA Kit

 Product Gene Name   

MYBPC3 clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    115197
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant MYBPC3. No significant cross-reactivity or interference between MYBPC3 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    31.25-2000pg/mL
 Sensitivity    18.75pg/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MYBPC3 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MYBPC3 clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of MYBPC3 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to MYBPC3. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for MYBPC3 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain MYBPC3, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of MYBPC3. You can calculate the concentration of MYBPC3 in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of MYBPC3 clia kit    MYBPC3 clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2530553. Click to request current manual
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NCBI/Uniprot data below describe general gene information for MYBPC3. It may not necessarily be applicable to this product.
 NCBI GI #    153217306
 NCBI GeneID    4607
 NCBI Accession #    AAI51212.1 [Other Products]
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 UniProt Secondary Accession #    Q16410; Q6R2F7; Q9UE27; Q9UM53; A5PL00 [Other Products]
 UniProt Related Accession #    Q14896 [Other Products]
 Molecular Weight    140,703 Da
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 NCBI Official Full Name    Myosin binding protein C, cardiac
 NCBI Official Synonym Full Names    myosin binding protein C, cardiac
 NCBI Official Symbol    MYBPC3 [Similar Products]
 NCBI Official Synonym Symbols   
FHC; CMH4; CMD1MM; LVNC10; MYBP-C
[Similar Products]
 NCBI Protein Information    myosin-binding protein C, cardiac-type
 UniProt Protein Name    Myosin-binding protein C, cardiac-type
 UniProt Synonym Protein Names   
C-protein, cardiac muscle isoform
 Protein Family    Myosin-binding protein
 UniProt Gene Name    MYBPC3 [Similar Products]
 UniProt Synonym Gene Names    Cardiac MyBP-C [Similar Products]
 UniProt Entry Name    MYPC3_HUMAN
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 NCBI Summary for MYBPC3    MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MYBPC3    MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family.

Protein type: Myosin-binding

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: sarcomere; striated muscle thick filament; cytosol; A band

Molecular Function: identical protein binding; ATPase activator activity; protein binding; myosin binding; structural constituent of muscle; metal ion binding; titin binding; actin binding; myosin heavy chain binding

Biological Process: heart morphogenesis; positive regulation of ATPase activity; regulation of heart rate; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; myosin filament assembly; cell adhesion; muscle filament sliding; cardiac muscle contraction

Disease: Left Ventricular Noncompaction 10; Cardiomyopathy, Familial Hypertrophic, 4
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 Research Articles on MYBPC3    1. Characterization of the novel splicing mutations in cardiomyopathy genes MYBPC3 and TNNT2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MYBPC3 clia kitPathways associated with MYBPC3 clia kit
 Reference Product  PubMed Publications
 MYH7 clia kit  >123 publications with MYBPC3 and MYH7
 TNNT2 clia kit  >78 publications with MYBPC3 and TNNT2
 TNNI3 clia kit  >55 publications with MYBPC3 and TNNI3
 TPM1 clia kit  >44 publications with MYBPC3 and TPM1
 MYL3 clia kit  >26 publications with MYBPC3 and MYL3
 MYL2 clia kit  >25 publications with MYBPC3 and MYL2
 TPM3 clia kit  >23 publications with MYBPC3 and TPM3
 MYH6 clia kit  >14 publications with MYBPC3 and MYH6
 TTN clia kit  >7 publications with MYBPC3 and TTN
 Products by Pathway  Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Organs/Tissues associated with MYBPC3 clia kit
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >138 publications with MYBPC3 and Heart
 Muscle Antibodies  >110 publications with MYBPC3 and Muscle
 Lung Antibodies  >5 publications with MYBPC3 and Lung
 Embryonic Tissue Antibodies  >1 publications with MYBPC3 and Embryonic Tissue
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