EAW66717.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
7,363 Da
NCBI Official Full Name
procollagen (type III) N-endopeptidase, isoform CRA_a, partial
NCBI Official Synonym Full Names
charged multivesicular body protein 1A
NCBI Official Synonym Symbols
PCH8; CHMP1; PRSM1; PCOLN3; VPS46A; VPS46-1 [Similar Products]
NCBI Protein Information
charged multivesicular body protein 1a
UniProt Protein Name
Charged multivesicular body protein 1a
UniProt Synonym Protein Names
Chromatin-modifying protein 1a; CHMP1a; Vacuolar protein sorting-associated protein 46-1; Vps46-1; hVps46-1
UniProt Synonym Gene Names
UniProt Entry Name
CHM1A_HUMAN
NCBI Summary for PCIII
This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
UniProt Comments for PCIII
CHMP1A: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. Belongs to the SNF7 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Cell cycle regulation
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: condensed nuclear chromosome; nuclear matrix; early endosome; microtubule organizing center; endomembrane system; endosome membrane
Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity; zinc ion binding; metallopeptidase activity
Biological Process: cell separation during cytokinesis; transcription, DNA-dependent; mitotic chromosome condensation; negative regulation of transcription by glucose; vacuolar transport; gene silencing; proteolysis; mitotic metaphase plate congression; vesicle-mediated transport; protein transport; cell division; negative regulation of transcription, DNA-dependent; nuclear organization and biogenesis
Disease: Pontocerebellar Hypoplasia, Type 8
Research Articles on PCIII
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Organs/Tissues associated with PCIII clia kit
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