AAI17194.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,136 Da
NCBI Official Full Name
Pappalysin 2
NCBI Official Synonym Full Names
pappalysin 2
NCBI Protein Information
pappalysin-2
UniProt Protein Name
Pappalysin-2
UniProt Synonym Protein Names
Pregnancy-associated plasma protein A2; PAPP-A2; Pregnancy-associated plasma protein E1; PAPP-E
UniProt Synonym Gene Names
UniProt Entry Name
PAPP2_HUMAN
NCBI Summary for PAPPA2
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
UniProt Comments for PAPPA2
PAPPA2: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. Belongs to the peptidase M43B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: membrane; extracellular region; intracellular
Molecular Function: metallopeptidase activity; zinc ion binding
Biological Process: cellular protein metabolic process; regulation of cell growth; proteolysis; cell differentiation
Research Articles on PAPPA2
Precautions
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Disclaimer
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Products associated with PAPPA2 clia kit
Pathways associated with PAPPA2 clia kit
Diseases associated with PAPPA2 clia kit
Organs/Tissues associated with PAPPA2 clia kit
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