AAH20633.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,010 Da
NCBI Official Full Name
Retinol binding protein 4, plasma
NCBI Official Synonym Full Names
retinol binding protein 4, plasma
NCBI Protein Information
retinol-binding protein 4
UniProt Protein Name
Retinol-binding protein 4
UniProt Synonym Protein Names
Plasma retinol-binding protein; PRBP; RBP
UniProt Synonym Gene Names
UniProt Entry Name
RET4_HUMAN
NCBI Summary for RBP4
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
UniProt Comments for RBP4
RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: extracellular space; protein complex; extracellular region; cytosol
Molecular Function: protein binding; protein heterodimerization activity; retinol binding; retinal binding
Biological Process: cardiac muscle development; phototransduction, visible light; response to retinoic acid; urinary bladder development; embryonic skeletal development; maintenance of gastrointestinal epithelium; heart development; vagina development; positive regulation of insulin secretion; positive regulation of immunoglobulin secretion; glucose homeostasis; uterus development; gluconeogenesis; embryonic organ morphogenesis; response to ethanol; visual perception; eye development; negative regulation of cardiac muscle cell proliferation; retinol metabolic process; embryonic retina morphogenesis in camera-type eye; retinoid metabolic process; female genitalia morphogenesis; lung development
Disease: Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome; Microphthalmia, Isolated, With Coloboma 10
Research Articles on RBP4
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Pathways associated with RBP4 clia kit
Organs/Tissues associated with RBP4 clia kit
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