NP_001077407.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
29,609 Da
NCBI Official Full Name
ribonuclease T2
NCBI Official Synonym Full Names
ribonuclease T2A
NCBI Official Synonym Symbols
C79750; Rnaset2; RNASE6PL; 0610007O07Rik; 4833423A10Rik; 4930532K22Rik [Similar Products]
NCBI Protein Information
ribonuclease T2
UniProt Protein Name
Ribonuclease T2
UniProt Synonym Protein Names
Ribonuclease 6
UniProt Synonym Gene Names
UniProt Entry Name
RNT2_MOUSE
UniProt Comments for RNASET2
RNASET2: Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM). An infantile- onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. Belongs to the RNase T2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ribonuclease; EC 3.1.27.-; Secreted; Secreted, signal peptide; RNA-binding
Cellular Component: extracellular space; lysosome; endoplasmic reticulum lumen
Molecular Function: ribonuclease activity
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Pathways associated with RNASET2 clia kit
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