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VWFCP/ADAMTS13 clia kit :: Human VWFCP/ADAMTS13 (Von Willebrand Factor Cleaving Protease) CLIA Kit

Scan QR to view Datasheet Catalog #    MBS2533107
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
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10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VWFCP/ADAMTS13 (Von Willebrand Factor Cleaving Protease), CLIA Kit

★Popular Item★
 Also Known As   

Human VWFCP/ADAMTS13 (Von Willebrand Factor Cleaving Protease) CLIA Kit

 Product Synonym Names    TTP; vWF-CP; C9orf8; ADAM metallopeptidase with thrombospondin type 1 motif, 13
 Product Gene Name   

VWFCP/ADAMTS13 clia kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    274150
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinant VWFCP/ADAMTS13. No significant cross-reactivity or interference between VWFCP/ADAMTS13 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    62.5-4000pg/mL
 Sensitivity    37.5pg/mL
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of VWFCP/ADAMTS13 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for VWFCP/ADAMTS13 clia kit

   Intended Uses: This CLIA kit applies to the in vitro quantitative determination of VWFCP/ADAMTS13 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to VWFCP/ADAMTS13. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for VWFCP/ADAMTS13 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain VWFCP/ADAMTS13, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of VWFCP/ADAMTS13. You can calculate the concentration of VWFCP/ADAMTS13 in the samples by comparing the RLU value of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of VWFCP/ADAMTS13 clia kit    VWFCP/ADAMTS13 clia kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2533107. Click to request current manual
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NCBI/Uniprot data below describe general gene information for VWFCP/ADAMTS13. It may not necessarily be applicable to this product.
 NCBI GI #    16306598
 NCBI GeneID    11093
 NCBI Accession #    AAL17652.1 [Other Products]
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 UniProt Secondary Accession #    Q6UY16; Q710F6; Q711T8; Q96L37; Q9H0G3; Q9UGQ1 [Other Products]
 UniProt Related Accession #    Q76LX8 [Other Products]
 Molecular Weight    39,864 Da
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 NCBI Official Full Name    von Willebrand factor-cleaving protease
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 13
 NCBI Official Symbol    ADAMTS13 [Similar Products]
 NCBI Official Synonym Symbols   
VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 13
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 13
 UniProt Synonym Protein Names   
von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease
 UniProt Gene Name    ADAMTS13 [Similar Products]
 UniProt Synonym Gene Names    C9orf8; ADAM-TS 13; ADAM-TS13; ADAMTS-13; vWF-CP; vWF-cleaving protease [Similar Products]
 UniProt Entry Name    ATS13_HUMAN
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 NCBI Summary for VWFCP/ADAMTS13    This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for VWFCP/ADAMTS13    ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding; Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Extracellular matrix; EC 3.4.24.87

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum lumen

Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding

Biological Process: integrin-mediated signaling pathway; platelet activation; protein amino acid O-linked glycosylation; cellular protein metabolic process; glycoprotein metabolic process; cell-matrix adhesion; response to toxin; peptide catabolic process; protein processing; post-translational protein modification; proteolysis

Disease: Thrombotic Thrombocytopenic Purpura, Congenital
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 Research Articles on VWFCP/ADAMTS13    1. Systemic inflammation complicating advanced cirrhosis is accompanied by reduced activity of ADAMTS13 promoting a prothrombotic function of von Willebrand factor, which can be employed to predict clinical outcome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with VWFCP/ADAMTS13 clia kitPathways associated with VWFCP/ADAMTS13 clia kit
 Reference Product  PubMed Publications
 VWF clia kit  >660 publications with VWFCP/ADAMTS13 and VWF
 C1R clia kit  >4 publications with VWFCP/ADAMTS13 and C1R
 FURIN clia kit  >3 publications with VWFCP/ADAMTS13 and FURIN
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Organs/Tissues associated with VWFCP/ADAMTS13 clia kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1047 publications with VWFCP/ADAMTS13 and Blood
 Kidney Antibodies  >135 publications with VWFCP/ADAMTS13 and Kidney
 Liver Antibodies  >105 publications with VWFCP/ADAMTS13 and Liver
 Brain Antibodies  >58 publications with VWFCP/ADAMTS13 and Brain
 Connective Tissue Antibodies  >18 publications with VWFCP/ADAMTS13 and Connective Tissue
 Nerve Antibodies  >7 publications with VWFCP/ADAMTS13 and Nerve
 Ovary Antibodies  >4 publications with VWFCP/ADAMTS13 and Ovary
 Intestine Antibodies  >3 publications with VWFCP/ADAMTS13 and Intestine
 Placenta Antibodies  >2 publications with VWFCP/ADAMTS13 and Placenta
 Eye Antibodies  >1 publications with VWFCP/ADAMTS13 and Eye
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