NP_002280.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,225 Da
NCBI Official Full Name
alpha-lactalbumin
NCBI Official Synonym Full Names
lactalbumin, alpha-
NCBI Protein Information
alpha-lactalbumin
UniProt Protein Name
Alpha-lactalbumin
UniProt Synonym Protein Names
Lactose synthase B protein; Lysozyme-like protein 7
UniProt Synonym Gene Names
UniProt Entry Name
LALBA_HUMAN
NCBI Summary for a-La
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
UniProt Comments for a-La
LALBA: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. Belongs to the glycosyl hydrolase 22 family.
Protein type: Secreted, signal peptide; Transferase; Apoptosis; Secreted
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: Golgi membrane; extracellular space; Golgi lumen
Molecular Function: lactose synthase activity; calcium ion binding
Biological Process: cell-cell signaling; apoptosis; carbohydrate metabolic process; defense response to bacterium; signal transduction; lactose biosynthetic process
Research Articles on a-La
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Products associated with a-La clia kit
Pathways associated with a-La clia kit
Organs/Tissues associated with a-La clia kit
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