NP_000005.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
163,291 Da
NCBI Official Full Name
alpha-2-macroglobulin
NCBI Official Synonym Full Names
alpha-2-macroglobulin
NCBI Protein Information
alpha-2-macroglobulin
UniProt Protein Name
Alpha-2-macroglobulin
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
UniProt Synonym Gene Names
UniProt Entry Name
A2MG_HUMAN
NCBI Summary for a2-M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
UniProt Comments for a2-M
A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: cytosol; extracellular region
Molecular Function: calcium-dependent protein binding; enzyme binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; protease binding; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; tumor necrosis factor binding
Biological Process: blood coagulation; blood coagulation, intrinsic pathway; extracellular matrix disassembly; extracellular matrix organization and biogenesis; negative regulation of complement activation, lectin pathway; platelet activation; platelet degranulation; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; stem cell differentiation
Disease: Alpha-2-macroglobulin Deficiency; Alzheimer Disease
Research Articles on a2-M
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Products associated with a2-M clia kit
Pathways associated with a2-M clia kit
Organs/Tissues associated with a2-M clia kit
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