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CD3 dual color reagent :: CD3/CD19 Dual Color Reagent

Scan QR to view Datasheet Catalog #    MBS238059
Testing Data #1
Unit / Price
50 Tests  /  $465 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD3/CD19, Dual Color Reagent

 Also Known As   

MOUSE ANTI HUMAN CD3:FITC/CD19:RPE

 Product Gene Name   

CD3 dual color reagent

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186740
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 Isotype    FITC reagent: IgG1 (MOUSE)
RPE reagent: IgG1 (MOUSE)
 Clone Number    UCHT1/LT19
 Host    Mouse
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 Specificity    UCHT1 recognises the human CD3 antigen, a complex of 5 polypeptide chains with molecular weights of 16-28kD, expressed by mature T cells.LT19 recognises the human CD19 antigen, a pan B cell marker.

This item may be used to simultaneously enumerate CD3 and CD19 positive cells.
 Form/Format    FITC/RPE
Dual Colour combination consisting of FITC conjugated and RPE conjugated monoclonal antibodies mixed in optimal ratio - lyophilised
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 Reconstitution    Reconstitute with 0.5 ml distilled water
Perservative Stabilisers
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of CD3 dual color reagent vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CD3 dual color reagent

   UCHT1 recognises the human CD3 antigen, a complex of 5 polypeptide chains with molecular weights of 16-28kD, expressed by mature T cells. LT19 recognises the human CD19 antigen, a pan B cell marker. MBS238059 may be used to simultaneously enumerate CD3 and CD19 positive cells.
 Applications Tested/Suitable for CD3 dual color reagent   

Flow cytometry (FC/FACS)

 Application Notes for CD3 dual color reagent    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data #1 of CD3 dual color reagent    MBS238059 staining of human lymphocytes
CD3 dual color reagent Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for CD3. It may not necessarily be applicable to this product.
 NCBI GI #    4557429
 NCBI GeneID    917
 NCBI Accession #    NP_000064.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000073.2 [Other Products]
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 UniProt Secondary Accession #    Q2HIZ6 [Other Products]
 UniProt Related Accession #    P09693 [Other Products]
 Molecular Weight    20,469 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD3 gamma chain
 NCBI Official Synonym Full Names    CD3g molecule, gamma (CD3-TCR complex)
 NCBI Official Symbol    CD3G [Similar Products]
 NCBI Official Synonym Symbols   
T3G; IMD17; CD3-GAMMA
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD3 gamma chain; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain
 UniProt Protein Name    T-cell surface glycoprotein CD3 gamma chain
 UniProt Synonym Protein Names   
T-cell receptor T3 gamma chain; CD_antigen: CD3g
 UniProt Gene Name    CD3G [Similar Products]
 UniProt Synonym Gene Names    T3G [Similar Products]
 UniProt Entry Name    CD3G_HUMAN
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 NCBI Summary for CD3    The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD3    CD3G: The CD3 complex mediates signal transduction.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; alpha-beta T cell receptor complex

Molecular Function: transmembrane receptor activity; receptor signaling complex scaffold activity; protein heterodimerization activity; T cell receptor binding

Biological Process: protein transport; regulation of immune response; cell surface receptor linked signal transduction; T cell activation; T cell costimulation; establishment and/or maintenance of cell polarity; innate immune response; protein complex assembly; T cell receptor signaling pathway

Disease: Immunodeficiency 17
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 Research Articles on CD3    1. The results suggest that CD3G should be studied as a candidate gene for autoimmunity and that CD3gamma deficiency should be considered among other primary immunodeficiencies with predominantly autoimmune manifestations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD3 dual color reagentPathways associated with CD3 dual color reagent
 Reference Product  PubMed Publications
 CD3D dual color reagent  >15 publications with CD3 and CD3D
 CD3E dual color reagent  >8 publications with CD3 and CD3E
 CD8A dual color reagent  >4 publications with CD3 and CD8A
 LCK dual color reagent  >4 publications with CD3 and LCK
 CD247 dual color reagent  >4 publications with CD3 and CD247
 FYN dual color reagent  >2 publications with CD3 and FYN
 ITK dual color reagent  >2 publications with CD3 and ITK
 CD8B dual color reagent  >1 publications with CD3 and CD8B
 PTPRC dual color reagent  >1 publications with CD3 and PTPRC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
Diseases associated with CD3 dual color reagentOrgans/Tissues associated with CD3 dual color reagent
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with CD3 and Inflammation
 Anemia Antibodies  >1 publications with CD3 and Anemia
 Carcinoma, Hepatocellular Antibodies  >1 publications with CD3 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with CD3 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with CD3 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >1 publications with CD3 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with CD3 and Blood
 Thymus Antibodies  >2 publications with CD3 and Thymus
 Brain Antibodies  >1 publications with CD3 and Brain
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