AAA63212.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,291 Da
NCBI Official Full Name
5-lipoxygenase, partial
NCBI Official Synonym Full Names
arachidonate 5-lipoxygenase
NCBI Protein Information
arachidonate 5-lipoxygenase
UniProt Protein Name
Arachidonate 5-lipoxygenase
UniProt Synonym Gene Names
UniProt Entry Name
LOX5_HUMAN
NCBI Summary for 5-LOX
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for 5-LOX
5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.
Protein type: EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: cytosol; extracellular space; nuclear envelope; nuclear envelope lumen; nuclear matrix; nuclear membrane
Molecular Function: arachidonate 5-lipoxygenase activity; iron ion binding; protein binding
Biological Process: leukotriene biosynthetic process; leukotriene metabolic process; lipoxygenase pathway
Disease: Asthma, Susceptibility To
Research Articles on 5-LOX
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Products associated with 5-LOX elisa kit
Pathways associated with 5-LOX elisa kit
Diseases associated with 5-LOX elisa kit
Organs/Tissues associated with 5-LOX elisa kit
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