NP_631894.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
134,205 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 14
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 14; ADAM-TS14; ADAMTS-14; ADAM-TS 14; metalloprotease-disintegrin protease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 14
UniProt Synonym Gene Names
UniProt Entry Name
ATS14_HUMAN
NCBI Summary for ADAMTS14
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS14
ADAMTS14: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. 4 isoforms of the human protein are produced by alternative promoter.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.24.-; Protease
Chromosomal Location of Human Ortholog: 10q21
Cellular Component: proteinaceous extracellular matrix; extracellular region
Molecular Function: zinc ion binding; metalloendopeptidase activity
Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; proteolysis
Research Articles on ADAMTS14
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Products associated with ADAMTS14 elisa kit
Pathways associated with ADAMTS14 elisa kit
Diseases associated with ADAMTS14 elisa kit
Organs/Tissues associated with ADAMTS14 elisa kit
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