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AKAP10 elisa kit :: Bovine A-kinase anchor protein 10, mitochondrial (AKAP10) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7215684 AKAP10 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A-kinase anchor protein 10, mitochondrial (AKAP10), ELISA Kit

 Also Known As   

Bovine A-kinase anchor protein 10, mitochondrial (AKAP10) ELISA Kit

 Product Gene Name   

AKAP10 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    604694
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 Species Reactivity    Bovine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AKAP10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AKAP10 purchase    MBS7215684 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A-kinase anchor protein 10, mitochondrial (AKAP10) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AKAP10. The ELISA analytical biochemical technique of the MBS7215684 kit is based on AKAP10 antibody-AKAP10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AKAP10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AKAP10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for AKAP10 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for AKAP10. It may not necessarily be applicable to this product.
 NCBI GI #    21493033
 NCBI GeneID    11216
 NCBI Accession #    NP_009133.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007202.3 [Other Products]
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 UniProt Secondary Accession #    Q96AJ7; B2R650 [Other Products]
 UniProt Related Accession #    O43572 [Other Products]
 Molecular Weight    73,818 Da
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 NCBI Official Full Name    A-kinase anchor protein 10, mitochondrial
 NCBI Official Synonym Full Names    A kinase (PRKA) anchor protein 10
 NCBI Official Symbol    AKAP10 [Similar Products]
 NCBI Official Synonym Symbols   
PRKA10; AKAP-10; D-AKAP2; D-AKAP-2
[Similar Products]
 NCBI Protein Information    A-kinase anchor protein 10, mitochondrial; protein kinase A anchoring protein 10; dual specificity A kinase-anchoring protein 2; mitochondrial A kinase PPKA anchor protein 10
 UniProt Protein Name    A-kinase anchor protein 10, mitochondrial
 UniProt Synonym Protein Names   
Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10
 Protein Family    A-kinase anchor protein
 UniProt Gene Name    AKAP10 [Similar Products]
 UniProt Synonym Gene Names    AKAP-10; D-AKAP-2; PRKA10 [Similar Products]
 UniProt Entry Name    AKA10_HUMAN
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 NCBI Summary for AKAP10    This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
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 UniProt Comments for AKAP10    AKAP10: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase. Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD). Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p11.1

Cellular Component: mitochondrion; cytoplasm; plasma membrane; cytosol

Biological Process: protein localization; signal transduction; blood coagulation

Disease: Cardiac Conduction Defect
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 Research Articles on AKAP10    1. Studied the clinicopathologic significance of A-kinase anchoring proteins 10 (AKAP 10) expression and the relationship with its polymorphism in colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AKAP10 elisa kitPathways associated with AKAP10 elisa kit
 Reference Product  PubMed Publications
 AKAP1 elisa kit  >2 publications with AKAP10 and AKAP1
 PRKAR2A elisa kit  >1 publications with AKAP10 and PRKAR2A
 PDZK1 elisa kit  >1 publications with AKAP10 and PDZK1
 PRKAR1A elisa kit  >1 publications with AKAP10 and PRKAR1A
 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with AKAP10 elisa kitOrgans/Tissues associated with AKAP10 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with AKAP10 and Nervous System Diseases
 Necrosis Antibodies  >2 publications with AKAP10 and Necrosis
 Brain Diseases Antibodies  >1 publications with AKAP10 and Brain Diseases
 Congenital Abnormalities Antibodies  >1 publications with AKAP10 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >1 publications with AKAP10 and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >7 publications with AKAP10 and Heart
 Blood Antibodies  >4 publications with AKAP10 and Blood
 Muscle Antibodies  >4 publications with AKAP10 and Muscle
 Kidney Antibodies  >4 publications with AKAP10 and Kidney
 Brain Antibodies  >3 publications with AKAP10 and Brain
 Embryonic Tissue Antibodies  >2 publications with AKAP10 and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with AKAP10 and Lymph Node
 Intestine Antibodies  >1 publications with AKAP10 and Intestine
 Testis Antibodies  >1 publications with AKAP10 and Testis
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