NP_996895.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,939 Da
NCBI Official Full Name
AP-3 complex subunit mu-1
NCBI Official Synonym Full Names
adaptor-related protein complex 3, mu 1 subunit
NCBI Protein Information
AP-3 complex subunit mu-1; mu3A-adaptin; mu-adaptin 3A; AP-3 adapter complex mu3A subunit; AP-3 adaptor complex mu3A subunit; clathrin adaptor complex AP3, mu-3A subunit; adapter-related protein complex 3 mu-1 subunit; adapter-related protein complex 3 subunit mu-1; adaptor-related protein complex 3 subunit mu-1
UniProt Protein Name
AP-3 complex subunit mu-1
UniProt Synonym Protein Names
AP-3 adaptor complex mu3A subunit; Adaptor-related protein complex 3 subunit mu-1; Mu-adaptin 3A; Mu3A-adaptin
UniProt Entry Name
AP3M1_HUMAN
NCBI Summary for AP3M1
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for AP3M1
AP3M1: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Belongs to the adaptor complexes medium subunit family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component: Golgi apparatus; cytoplasmic vesicle membrane; clathrin adaptor complex; lysosome; lysosomal membrane
Molecular Function: protein binding; Rab GTPase binding
Biological Process: protein targeting to lysosome; anterograde synaptic vesicle transport; anterograde axon cargo transport
Research Articles on AP3M1
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Products associated with AP3M1 elisa kit
Pathways associated with AP3M1 elisa kit
Diseases associated with AP3M1 elisa kit
Organs/Tissues associated with AP3M1 elisa kit
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