NP_005150.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,019 Da
NCBI Official Full Name
actin, alpha cardiac muscle 1 proprotein
NCBI Official Synonym Full Names
actin, alpha, cardiac muscle 1
NCBI Official Synonym Symbols
ACTC; ASD5; CMD1R; CMH11; LVNC4 [Similar Products]
NCBI Protein Information
actin, alpha cardiac muscle 1
UniProt Protein Name
Actin, alpha cardiac muscle 1
UniProt Synonym Protein Names
Alpha-cardiac actin
UniProt Synonym Gene Names
UniProt Entry Name
ACTC_HUMAN
NCBI Summary for ACTC1
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]
UniProt Comments for ACTC1
ACTC1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family.
Protein type: Motility/polarity/chemotaxis; Myosin-binding; Contractile; Cytoskeletal; Cell development/differentiation
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: I band; extracellular space; sarcomere; focal adhesion; membrane; cytoplasm; actin filament; cytosol
Molecular Function: myosin binding; ATPase activity; ATP binding
Biological Process: response to drug; metabolic process; muscle thin filament assembly; apoptosis; actin filament-based movement; actomyosin structure organization and biogenesis; cardiac myofibril assembly; muscle filament sliding; response to ethanol; heart contraction; cardiac muscle morphogensis; actin-myosin filament sliding; cardiac muscle contraction; negative regulation of apoptosis
Disease: Cardiomyopathy, Familial Hypertrophic, 11; Atrial Septal Defect 5; Cardiomyopathy, Dilated, 1r
Research Articles on ACTC1
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Products associated with ACTC1 elisa kit
Pathways associated with ACTC1 elisa kit
Diseases associated with ACTC1 elisa kit
Disease Name |
Pubmed Publications |
Heart Defects, Congenital Antibodies |
>9 publications with ACTC1 and Heart Defects, Congenital |
Cardiomyopathy, Dilated Antibodies |
>8 publications with ACTC1 and Cardiomyopathy, Dilated |
Cardiomyopathy, Familial Hypertrophic, 1 Antibodies |
>4 publications with ACTC1 and Cardiomyopathy, Familial Hypertrophic, 1 |
Hypertrophy Antibodies |
>3 publications with ACTC1 and Hypertrophy |
Disease Models, Animal Antibodies |
>2 publications with ACTC1 and Disease Models, Animal |
Lung Neoplasms Antibodies |
>2 publications with ACTC1 and Lung Neoplasms |
Lung Diseases Antibodies |
>2 publications with ACTC1 and Lung Diseases |
Cardiomyopathy, Familial Hypertrophic, 11 Antibodies |
>2 publications with ACTC1 and Cardiomyopathy, Familial Hypertrophic, 11 |
Neoplasms, Experimental Antibodies |
>1 publications with ACTC1 and Neoplasms, Experimental |
Refractive Errors Antibodies |
>1 publications with ACTC1 and Refractive Errors |
Organs/Tissues associated with ACTC1 elisa kit
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