NP_001091.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,051 Da
NCBI Official Full Name
actin, alpha skeletal muscle
NCBI Official Synonym Full Names
actin, alpha 1, skeletal muscle
NCBI Official Synonym Symbols
ACTA; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM [Similar Products]
NCBI Protein Information
actin, alpha skeletal muscle; nemaline myopathy type 3
UniProt Protein Name
Actin, alpha skeletal muscle
UniProt Synonym Protein Names
Alpha-actin-1
UniProt Synonym Gene Names
UniProt Entry Name
ACTS_HUMAN
NCBI Summary for ACTA1
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]
UniProt Comments for ACTA1
ACTA1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family.
Protein type: Cytoskeletal; Cell development/differentiation; Motility/polarity/chemotaxis; Contractile
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: extracellular space; sarcomere; stress fiber; actin filament; cytosol; striated muscle thin filament; actin cytoskeleton
Molecular Function: protein binding; myosin binding; structural constituent of cytoskeleton; ADP binding; ATP binding
Biological Process: skeletal muscle fiber adaptation; muscle contraction; response to steroid hormone stimulus; muscle thin filament assembly; response to mechanical stimulus; response to lithium ion; response to extracellular stimulus; skeletal muscle fiber development; cell growth; muscle filament sliding
Disease: Nemaline Myopathy 3; Myopathy, Congenital, With Fiber-type Disproportion
Research Articles on ACTA1
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Products associated with ACTA1 elisa kit
Pathways associated with ACTA1 elisa kit
Diseases associated with ACTA1 elisa kit
Organs/Tissues associated with ACTA1 elisa kit
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