NP_001120.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
82,183 Da
NCBI Official Full Name
adipocyte enhancer-binding protein 1
NCBI Official Synonym Full Names
AE binding protein 1
NCBI Official Synonym Symbols
NCBI Protein Information
adipocyte enhancer-binding protein 1; aortic carboxypeptidase-like protein
UniProt Protein Name
Adipocyte enhancer-binding protein 1
UniProt Synonym Protein Names
Aortic carboxypeptidase-like protein
UniProt Synonym Gene Names
UniProt Entry Name
AEBP1_HUMAN
NCBI Summary for AEBP1
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
UniProt Comments for AEBP1
AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p13
Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus
Molecular Function: calmodulin binding; carboxypeptidase activity; zinc ion binding; transcription factor activity; transcription corepressor activity; metallocarboxypeptidase activity
Biological Process: muscle development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; proteolysis; skeletal development
Research Articles on AEBP1
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Products associated with AEBP1 elisa kit
Diseases associated with AEBP1 elisa kit
Organs/Tissues associated with AEBP1 elisa kit
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