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AM elisa kit :: Bovine Adrenomedullin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS005146 AM elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Adrenomedullin (AM), ELISA Kit

 Also Known As   

Bovine Adrenomedullin ELISA Kit

 Product Gene Name   

AM elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 11; NC_000011.9 (10326642..10328923). Location: 11p15.4
 OMIM    103275
 3D Structure    ModBase 3D Structure for P35318
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 Species Reactivity    Bovine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of AM elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for AM purchase    MBS005146 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Adrenomedullin (AM) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AM. The ELISA analytical biochemical technique of the MBS005146 kit is based on AM antibody-AM antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AM antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AM. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for AM. It may not necessarily be applicable to this product.
 NCBI GI #    765330
 NCBI GeneID    133
 NCBI Accession #    AAC60642.1 [Other Products]
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 UniProt Primary Accession #    P35318 [Other Products]
 UniProt Secondary Accession #    Q6FGW2; B2R793; D3DQV3 [Other Products]
 UniProt Related Accession #    P35318 [Other Products]
 Molecular Weight    20,420 Da
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 NCBI Official Full Name    adrenomedullin
 NCBI Official Synonym Full Names    adrenomedullin
 NCBI Official Symbol    ADM [Similar Products]
 NCBI Official Synonym Symbols   
AM
[Similar Products]
 NCBI Protein Information    ADM; preproadrenomedullin
 UniProt Protein Name    ADM
 UniProt Synonym Protein Names   
ProAM N-terminal 20 peptide
 UniProt Gene Name    ADM [Similar Products]
 UniProt Synonym Gene Names    AM; AM; PAMP; ProAM-N20 [Similar Products]
 UniProt Entry Name    ADML_HUMAN
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 NCBI Summary for AM    Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AM    ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: protein binding; adrenomedullin receptor binding; hormone activity; receptor binding

Biological Process: developmental growth; positive regulation of apoptosis; blood circulation; heart development; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; signal transduction; positive regulation of vasodilation; response to insulin stimulus; negative regulation of cell proliferation; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; cell-cell signaling; receptor internalization; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; response to wounding; vasculogenesis; regulation of the force of heart contraction; aging; hormone secretion; organ regeneration; progesterone biosynthetic process; androgen metabolic process; neurite regeneration; positive regulation of heart rate; negative regulation of vasoconstriction; odontogenesis of dentine-containing teeth; response to starvation; positive regulation of angiogenesis; G-protein coupled receptor internalization; neural tube closure; response to hypoxia; negative regulation of vascular permeability; cAMP biosynthetic process; response to cold
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 Research Articles on AM    1. we conclude that ADM expression is highly correlated with the degree of malignancy and metastasis of osteosarcoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AM elisa kitPathways associated with AM elisa kit
 Reference Product  PubMed Publications
 HIF1A elisa kit  >15 publications with AM and HIF1A
 POMC elisa kit  >11 publications with AM and POMC
 ADM2 elisa kit  >10 publications with AM and ADM2
 IAPP elisa kit  >3 publications with AM and IAPP
 EDN1 elisa kit  >2 publications with AM and EDN1
 NPPA elisa kit  >1 publications with AM and NPPA
 CFH elisa kit  >1 publications with AM and CFH
 CALCB elisa kit  >1 publications with AM and CALCB
 CALCA elisa kit  >1 publications with AM and CALCA
 Products by Pathway  Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with AM elisa kitOrgans/Tissues associated with AM elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2093 publications with AM and Neoplasms
 Nervous System Diseases Antibodies  >717 publications with AM and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >521 publications with AM and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >362 publications with AM and Liver Neoplasms
 Liver Diseases Antibodies  >360 publications with AM and Liver Diseases
 Lung Diseases Antibodies  >336 publications with AM and Lung Diseases
 Breast Neoplasms Antibodies  >298 publications with AM and Breast Neoplasms
 Drug Toxicity Antibodies  >271 publications with AM and Drug Toxicity
 Heart Diseases Antibodies  >269 publications with AM and Heart Diseases
 Neoplasms, Experimental Antibodies  >267 publications with AM and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1073 publications with AM and Blood
 Muscle Antibodies  >577 publications with AM and Muscle
 Liver Antibodies  >546 publications with AM and Liver
 Bone Antibodies  >543 publications with AM and Bone
 Vascular Antibodies  >491 publications with AM and Vascular
 Heart Antibodies  >481 publications with AM and Heart
 Lung Antibodies  >426 publications with AM and Lung
 Brain Antibodies  >387 publications with AM and Brain
 Skin Antibodies  >329 publications with AM and Skin
 Mouth Antibodies  >276 publications with AM and Mouth
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