View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List ANGPT-1 elisa kit :: Bovine Angiopoietin 1 (ANGPT-1) ELISA Kit Catalog # MBS2608771 Unit / Price 48-Strip-Wells / $325 +1 FREE 8GB USB 96-Strip-Wells / $490 +1 FREE 8GB USB 5x96-Strip-Wells / $2,025 +2 FREE 8GB USB 10x96-Strip-Wells / $3,725 +4 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Angiopoietin 1 (ANGPT-1), ELISA Kit Full Product Name Bovine Angiopoietin 1 (ANGPT-1) ELISA Kit Product Gene Name ANGPT-1 elisa kit[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Request for Current Manual Insert Request Current Manual OMIM U83508 mRNA Species Reactivity Bovine Preparation and Storage Store all reagents at 2-8 degree C. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Product Note Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details. Other Notes Small volumes of ANGPT-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. Searchable Terms for ANGPT-1 purchase MBS2608771 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Angiopoietin 1 (ANGPT-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ANGPT-1. The ELISA analytical biochemical technique of the MBS2608771 kit is based on ANGPT-1 antibody-ANGPT-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ANGPT-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ANGPT-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%). TOP NCBI/Uniprot data below describe general gene information for ANGPT-1. It may not necessarily be applicable to this product. NCBI GI # 22203641 NCBI GeneID 284 UniProt Secondary Accession # Q5HYA0[Other Products] UniProt Related Accession # Q15389[Other Products] Molecular Weight 57,456 Da TOP NCBI Official Full Name angiopoietin 1 NCBI Official Synonym Full Names angiopoietin 1 NCBI Official Symbol ANGPT1 [Similar Products] NCBI Official Synonym Symbols AGP1; AGPT; ANG1 [Similar Products] NCBI Protein Information angiopoietin-1 UniProt Protein Name Angiopoietin-1 UniProt Gene Name ANGPT1 [Similar Products] UniProt Synonym Gene Names KIAA0003; ANG-1 [Similar Products] UniProt Entry Name ANGP1_HUMAN TOP NCBI Summary for ANGPT-1 This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015] TOP UniProt Comments for ANGPT-1 ANGPT1: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 8q23.1Cellular Component: extracellular region; extracellular space; lipid raft; microvillus; plasma membraneMolecular Function: Ras guanyl-nucleotide exchange factor activity; receptor tyrosine kinase bindingBiological Process: heparin biosynthetic process; leukocyte migration; MAPKKK cascade; negative regulation of apoptosis; negative regulation of cell adhesion; negative regulation of vascular permeability; positive chemotaxis; positive regulation of blood vessel endothelial cell migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of protein ubiquitination; positive regulation of receptor internalization; regulation of endothelial cell proliferation; regulation of satellite cell proliferation; sprouting angiogenesis; Tie receptor signaling pathway; transmembrane receptor protein tyrosine kinase activation (dimerization) Research Articles on ANGPT-1 1. the homeostasis of vascular endothelial function by Ang-1 and Ang-2 is disrupted in macrophage activation syndrome (MAS); the Ang-2/1 ratio was significantly elevated in the active phase of s-JIA; serum Ang-1 levels were significantly decreased in MAS, whereas the serum Ang-2 levels and the Ang-2/1 ratio were significantly elevated in MAS TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with ANGPT-1 elisa kit Reference Product PubMed Publications ANGPT2 elisa kit >360 publications with ANGPT-1 and ANGPT2 VEGFA elisa kit >103 publications with ANGPT-1 and VEGFA TEK elisa kit >44 publications with ANGPT-1 and TEK KDR elisa kit >18 publications with ANGPT-1 and KDR FLT1 elisa kit >13 publications with ANGPT-1 and FLT1 MMP2 elisa kit >7 publications with ANGPT-1 and MMP2 ELF2 elisa kit >1 publications with ANGPT-1 and ELF2 Pathways associated with ANGPT-1 elisa kit Products by Pathway Pathway Diagram ARMS-mediated Activation Pathway antibodies ARMS-mediated Activation Pathway Diagram Angiogenesis Pathway antibodies Angiogenesis Pathway Diagram Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram Axon Guidance Pathway antibodies Axon Guidance Pathway Diagram Cell Surface Interactions At The Vascular Wall Pathway antibodies Cell Surface Interactions At The Vascular Wall Pathway Diagram Cytokine Signaling In Immune System Pathway antibodies Cytokine Signaling In Immune System Pathway Diagram DAP12 Interactions Pathway antibodies DAP12 Interactions Pathway Diagram DAP12 Signaling Pathway antibodies DAP12 Signaling Pathway Diagram Developmental Biology Pathway antibodies Developmental Biology Pathway Diagram Downstream Signal Transduction Pathway antibodies Downstream Signal Transduction Pathway Diagram Diseases associated with ANGPT-1 elisa kit Disease Name Pubmed Publications Disease Models, Animal Antibodies >82 publications with ANGPT-1 and Disease Models, Animal Inflammation Antibodies >78 publications with ANGPT-1 and Inflammation Nervous System Diseases Antibodies >47 publications with ANGPT-1 and Nervous System Diseases Heart Diseases Antibodies >37 publications with ANGPT-1 and Heart Diseases Lung Diseases Antibodies >36 publications with ANGPT-1 and Lung Diseases Necrosis Antibodies >26 publications with ANGPT-1 and Necrosis Edema Antibodies >25 publications with ANGPT-1 and Edema Kidney Diseases Antibodies >24 publications with ANGPT-1 and Kidney Diseases Hypertension Antibodies >23 publications with ANGPT-1 and Hypertension Neoplasms, Experimental Antibodies >22 publications with ANGPT-1 and Neoplasms, Experimental Organs/Tissues associated with ANGPT-1 elisa kit Organ/Tissue Name Pubmed Publications Vascular Antibodies >524 publications with ANGPT-1 and Vascular Blood Antibodies >381 publications with ANGPT-1 and Blood Muscle Antibodies >106 publications with ANGPT-1 and Muscle Bone Antibodies >66 publications with ANGPT-1 and Bone Brain Antibodies >66 publications with ANGPT-1 and Brain Heart Antibodies >65 publications with ANGPT-1 and Heart Embryonic Tissue Antibodies >59 publications with ANGPT-1 and Embryonic Tissue Lung Antibodies >48 publications with ANGPT-1 and Lung Bone Marrow Antibodies >47 publications with ANGPT-1 and Bone Marrow Liver Antibodies >41 publications with ANGPT-1 and Liver TOP