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ANK1 elisa kit :: Bovine Ankyrin-1 (ANK1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7228792 ANK1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ankyrin-1 (ANK1), ELISA Kit

 Also Known As   

Bovine Ankyrin-1 (ANK1) ELISA Kit

 Product Gene Name   

ANK1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    612641
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 Species Reactivity    Bovine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ANK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ANK1 purchase    MBS7228792 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Ankyrin-1 (ANK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ANK1. The ELISA analytical biochemical technique of the MBS7228792 kit is based on ANK1 antibody-ANK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ANK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ANK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for ANK1 elisa kit    Cardiovascular
NCBI/Uniprot data below describe general gene information for ANK1. It may not necessarily be applicable to this product.
 NCBI GI #    215598574
 NCBI GeneID    286
 NCBI Accession #    NP_001135918.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142446.1 [Other Products]
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 UniProt Secondary Accession #    O43400; Q13768; Q53ER1; Q59FP2; Q8N604; Q99407; A0PJN8; A6NJ23; E5RFL7 [Other Products]
 UniProt Related Accession #    P16157 [Other Products]
 Molecular Weight    17,854 Da
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 NCBI Official Full Name    ankyrin-1 isoform 9
 NCBI Official Synonym Full Names    ankyrin 1, erythrocytic
 NCBI Official Symbol    ANK1 [Similar Products]
 NCBI Official Synonym Symbols   
ANK; SPH1; SPH2
[Similar Products]
 NCBI Protein Information    ankyrin-1; ANK-1; ankyrin-R; erythrocyte ankyrin
 UniProt Protein Name    Ankyrin-1
 UniProt Synonym Protein Names   
Ankyrin-R; Erythrocyte ankyrin
 Protein Family    Ankyrin
 UniProt Gene Name    ANK1 [Similar Products]
 UniProt Synonym Gene Names    ANK; ANK-1 [Similar Products]
 UniProt Entry Name    ANK1_HUMAN
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 NCBI Summary for ANK1    Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
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 UniProt Comments for ANK1    ANK1: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Defects in ANK1 are a cause of spherocytosis type 1 (SPH1); also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive. 21 isoforms of the human protein are produced by alternative promoter.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Endoplasmic reticulum; Cell development/differentiation

Chromosomal Location of Human Ortholog: 8p11.1

Cellular Component: cortical cytoskeleton; postsynaptic membrane; cytoskeleton; sarcoplasmic reticulum; basolateral plasma membrane; plasma membrane; M band; axolemma; cytosol; nucleus; Z disc; sarcolemma

Molecular Function: protein binding; enzyme binding; spectrin binding; structural constituent of cytoskeleton; cytoskeletal adaptor activity; structural molecule activity; ATPase binding

Biological Process: axon guidance; iron ion homeostasis; ER to Golgi vesicle-mediated transport; erythrocyte development; exocytosis; monovalent inorganic cation transport; cytoskeleton organization and biogenesis; signal transduction; maintenance of epithelial cell polarity; porphyrin biosynthetic process

Disease: Spherocytosis, Type 1
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 Research Articles on ANK1    1. ANK1 rs516946 confers impaired insulin release.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANK1 elisa kitPathways associated with ANK1 elisa kit
 Reference Product  PubMed Publications
 SPTB elisa kit  >10 publications with ANK1 and SPTB
 OBSCN elisa kit  >9 publications with ANK1 and OBSCN
 SPTA1 elisa kit  >9 publications with ANK1 and SPTA1
 SLC4A1 elisa kit  >7 publications with ANK1 and SLC4A1
 CD44 elisa kit  >1 publications with ANK1 and CD44
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Neurofascin Interactions Pathway antibodies  Neurofascin Interactions Pathway Diagram
 NrCAM Interactions Pathway antibodies  NrCAM Interactions Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
Diseases associated with ANK1 elisa kitOrgans/Tissues associated with ANK1 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with ANK1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >3 publications with ANK1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with ANK1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with ANK1 and Kidney Diseases
 Urogenital Abnormalities Antibodies  >2 publications with ANK1 and Urogenital Abnormalities
 Congenital Abnormalities Antibodies  >2 publications with ANK1 and Congenital Abnormalities
 Prostatic Neoplasms Antibodies  >2 publications with ANK1 and Prostatic Neoplasms
 Disorders of Sex Development Antibodies  >2 publications with ANK1 and Disorders of Sex Development
 Edema Antibodies  >2 publications with ANK1 and Edema
 Hypertrophy Antibodies  >2 publications with ANK1 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >44 publications with ANK1 and Blood
 Muscle Antibodies  >26 publications with ANK1 and Muscle
 Heart Antibodies  >7 publications with ANK1 and Heart
 Brain Antibodies  >7 publications with ANK1 and Brain
 Embryonic Tissue Antibodies  >4 publications with ANK1 and Embryonic Tissue
 Spleen Antibodies  >3 publications with ANK1 and Spleen
 Bone Antibodies  >3 publications with ANK1 and Bone
 Nerve Antibodies  >2 publications with ANK1 and Nerve
 Lymph Node Antibodies  >2 publications with ANK1 and Lymph Node
 Prostate Antibodies  >2 publications with ANK1 and Prostate
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