P08519.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
501,319 Da
NCBI Official Full Name
Apolipoprotein(a)
NCBI Official Synonym Full Names
lipoprotein, Lp(a)
NCBI Protein Information
apolipoprotein(a); apolipoprotein(a); lp(a); apo(a); antiangiogenic AK38 protein
UniProt Protein Name
Apolipoprotein(a)
UniProt Synonym Gene Names
UniProt Entry Name
APOA_HUMAN
NCBI Summary for LPA
The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
UniProt Comments for LPA
LPA: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. Belongs to the peptidase S1 family. Plasminogen subfamily.
Protein type: Inhibitor; EC 3.4.21.-; Protease
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: extracellular region
Molecular Function: heparin binding; protein binding; fibronectin binding; serine-type endopeptidase activity; endopeptidase inhibitor activity; apolipoprotein binding
Biological Process: receptor-mediated endocytosis; blood circulation; lipoprotein metabolic process; lipid metabolic process; lipid transport; proteolysis
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Products associated with LPA elisa kit
Pathways associated with LPA elisa kit
Organs/Tissues associated with LPA elisa kit
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