NP_001002036.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,936 Da
NCBI Official Full Name
astacin-like metalloendopeptidase
NCBI Official Synonym Full Names
astacin-like metallo-endopeptidase (M12 family)
NCBI Official Synonym Symbols
NCBI Protein Information
astacin-like metalloendopeptidase; ovastacin; oocyte astacin; sperm acrosomal SLLP1 binding; astacin-like metalloendopeptidase (M12 family)
UniProt Protein Name
Astacin-like metalloendopeptidase
UniProt Synonym Protein Names
Oocyte astacin; Ovastacin
UniProt Entry Name
ASTL_HUMAN
UniProt Comments for ASTL
ASTL: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. Belongs to the peptidase M12A family.
Protein type: Protease; EC 3.4.-.-
Chromosomal Location of Human Ortholog: 2q11.1
Cellular Component: transport vesicle; cytoplasm; plasma membrane
Molecular Function: peptidase activity; zinc ion binding; metalloendopeptidase activity
Biological Process: fertilization; cell adhesion; proteolysis
Research Articles on ASTL
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Diseases associated with ASTL elisa kit
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