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bcl-xl elisa kit :: Bovine B Cell Leukemia X long ELISA Kit

Scan QR to view Datasheet Catalog #    MBS750500 bcl-xl elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B Cell Leukemia X long (bcl-xl), ELISA Kit

 Also Known As   

Bovine B Cell Leukemia X long ELISA Kit

 Product Gene Name   

bcl-xl elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    600039
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 Species Reactivity    Bovine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Intended Uses    This bcl-xl ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Bovine bcl-xl. This ELISA kit for research use only, not for therapeutic or diagnostic applications
 !Intended Uses    This bcl-xl ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Bovine bcl-xl. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of bcl-xl elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for bcl-xl purchase    MBS750500 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the B Cell Leukemia X long (bcl-xl) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing bcl-xl. The ELISA analytical biochemical technique of the MBS750500 kit is based on bcl-xl antibody-bcl-xl antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect bcl-xl antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, bcl-xl. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for bcl-xl elisa kit

   Principle of the Assay: bcl-xl ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-bcl-xl antibody and an bcl-xl-HRP conjugate. The assay sample and buffer are incubated together with bcl-xl-HRP conjugate in pre-coated plate for one hour. After the incubation period, the wells are decanted and washed five times. The wells are then incubated with a substrate for HRP enzyme. The product of the enzyme-substrate reaction forms a blue colored complex. Finally, a stop solution is added to stop the reaction, which will then turn the solution yellow. The intensity of color is measured spectrophotometrically at 450nm in a microplate reader. The intensity of the color is inversely proportional to the bcl-xl concentration since bcl-xl from samples and bcl-xl-HRP conjugate compete for the anti-bcl-xl antibody binding site. Since the number of sites is limited, as more sites are occupied by bcl-xl from the sample, fewer sites are left to bind bcl-xl-HRP conjugate. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The bcl-xl concentration in each sample is interpolated from this standard curve.
 Product Categories/Family for bcl-xl elisa kit    Cell Biology
Sample Manual Insert of MBS750500. Click to request current manual
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NCBI/Uniprot data below describe general gene information for bcl-xl. It may not necessarily be applicable to this product.
 NCBI GI #    20336335
 NCBI GeneID    598
 NCBI Accession #    NP_612815.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_138578.1 [Other Products]
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 UniProt Secondary Accession #    Q5CZ89; Q5TE65; Q92976; E1P5L6 [Other Products]
 UniProt Related Accession #    Q07817 [Other Products]
 Molecular Weight    25,290 Da
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 NCBI Official Full Name    bcl-2-like protein 1 isoform 1
 NCBI Official Synonym Full Names    BCL2-like 1
 NCBI Official Symbol    BCL2L1 [Similar Products]
 NCBI Official Synonym Symbols   
BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; PPP1R52; BCL-XL/S
[Similar Products]
 NCBI Protein Information    bcl-2-like protein 1; apoptosis regulator Bcl-X; protein phosphatase 1, regulatory subunit 52
 UniProt Protein Name    Bcl-2-like protein 1
 UniProt Synonym Protein Names   
Apoptosis regulator Bcl-X
 UniProt Gene Name    BCL2L1 [Similar Products]
 UniProt Synonym Gene Names    BCL2L; BCLX; Bcl2-L-1 [Similar Products]
 UniProt Entry Name    B2CL1_HUMAN
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 NCBI Summary for bcl-xl    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
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 UniProt Comments for bcl-xl    Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.

Protein type: Membrane protein, integral; Apoptosis; Autophagy; Mitochondrial

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: centrosome; nuclear membrane; synaptic vesicle membrane; mitochondrion; integral to membrane; cytosol; mitochondrial outer membrane; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; nucleolus; cell junction; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; BH3 domain binding; protein kinase binding

Biological Process: negative regulation of autophagy; apoptosis; cytokinesis; cellular process regulating host cell cycle in response to virus; germ cell development; apoptotic mitochondrial changes; ovarian follicle development; regulation of mitochondrial membrane potential; positive regulation of cell proliferation; negative regulation of neuron apoptosis; release of cytochrome c from mitochondria; in utero embryonic development; mitotic cell cycle checkpoint; male gonad development; suppression by virus of host apoptosis; endocytosis; cell proliferation; neuron apoptosis; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; response to cycloheximide; innate immune response; spermatogenesis; regulation of mitochondrial membrane permeability; growth; negative regulation of apoptosis
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 Research Articles on bcl-xl    1. IL-33/ST2 axis promotes mast cell survival via BCLXL.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with bcl-xl elisa kitPathways associated with bcl-xl elisa kit
 Reference Product  PubMed Publications
 BAX elisa kit  >2180 publications with bcl-xl and BAX
 BAD elisa kit  >545 publications with bcl-xl and BAD
 BID elisa kit  >341 publications with bcl-xl and BID
 BAK1 elisa kit  >238 publications with bcl-xl and BAK1
 TP53 elisa kit  >63 publications with bcl-xl and TP53
 APAF1 elisa kit  >60 publications with bcl-xl and APAF1
 BECN1 elisa kit  >50 publications with bcl-xl and BECN1
 BIK elisa kit  >49 publications with bcl-xl and BIK
 BBC3 elisa kit  >44 publications with bcl-xl and BBC3
 BCL2L11 elisa kit  >7 publications with bcl-xl and BCL2L11
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies  BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with bcl-xl elisa kitOrgans/Tissues associated with bcl-xl elisa kit
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >834 publications with bcl-xl and Carcinoma
 Necrosis Antibodies  >650 publications with bcl-xl and Necrosis
 Nervous System Diseases Antibodies  >374 publications with bcl-xl and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >293 publications with bcl-xl and Gastrointestinal Diseases
 Brain Diseases Antibodies  >290 publications with bcl-xl and Brain Diseases
 Breast Neoplasms Antibodies  >261 publications with bcl-xl and Breast Neoplasms
 Liver Diseases Antibodies  >249 publications with bcl-xl and Liver Diseases
 Neoplasms, Experimental Antibodies  >230 publications with bcl-xl and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >185 publications with bcl-xl and Liver Neoplasms
 Inflammation Antibodies  >185 publications with bcl-xl and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1310 publications with bcl-xl and Blood
 Brain Antibodies  >537 publications with bcl-xl and Brain
 Liver Antibodies  >429 publications with bcl-xl and Liver
 Lung Antibodies  >300 publications with bcl-xl and Lung
 Bone Antibodies  >267 publications with bcl-xl and Bone
 Vascular Antibodies  >262 publications with bcl-xl and Vascular
 Muscle Antibodies  >235 publications with bcl-xl and Muscle
 Prostate Antibodies  >199 publications with bcl-xl and Prostate
 Heart Antibodies  >193 publications with bcl-xl and Heart
 Kidney Antibodies  >168 publications with bcl-xl and Kidney
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