NP_001534.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NCBI Official Synonym Full Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NCBI Official Synonym Symbols
NCBI Protein Information
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; NDST-1; HSNST 1; N-HSST 1; N-heparan sulfate sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; [Heparan sulfate]-glucosamine N-sulfotransferase 1
UniProt Protein Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
UniProt Synonym Protein Names
Glucosaminyl N-deacetylase/N-sulfotransferase 1; NDST-1; N-heparan sulfate sulfotransferase 1; N-HSST 1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; HSNST 1
UniProt Synonym Gene Names
UniProt Entry Name
NDST1_HUMAN
NCBI Summary for NDST1
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for NDST1
NDST1: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response. Belongs to the sulfotransferase 1 family. NDST subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; EC 2.8.2.8; Hydrolase; Transferase
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity
Biological Process: smoothened signaling pathway; fibroblast growth factor receptor signaling pathway; glycosaminoglycan metabolic process; MAPKKK cascade; pathogenesis; embryonic viscerocranium morphogenesis; respiratory gaseous exchange; glycosaminoglycan biosynthetic process; polysaccharide biosynthetic process; heparin biosynthetic process; forebrain development; heparan sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; midbrain development; embryonic neurocranium morphogenesis; inflammatory response
Disease: Mental Retardation, Autosomal Recessive 46
Research Articles on NDST1
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Products associated with NDST1 elisa kit
Pathways associated with NDST1 elisa kit
Diseases associated with NDST1 elisa kit
Organs/Tissues associated with NDST1 elisa kit
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