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MAPK8IP1 elisa kit :: Bovine C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7204997 MAPK8IP1 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1), ELISA Kit

 Also Known As   

Bovine C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) ELISA Kit

 Product Gene Name   

MAPK8IP1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    604641
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 Species Reactivity    Bovine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MAPK8IP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MAPK8IP1 purchase    MBS7204997 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MAPK8IP1. The ELISA analytical biochemical technique of the MBS7204997 kit is based on MAPK8IP1 antibody-MAPK8IP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MAPK8IP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MAPK8IP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for MAPK8IP1 elisa kit    Epigenetics and Nuclear Signaling
NCBI/Uniprot data below describe general gene information for MAPK8IP1. It may not necessarily be applicable to this product.
 NCBI GI #    4885433
 NCBI GeneID    9479
 NCBI Accession #    NP_005447.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005456.3 [Other Products]
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 UniProt Secondary Accession #    O43407; D3DQP4 [Other Products]
 UniProt Related Accession #    Q9UQF2 [Other Products]
 Molecular Weight    77,524 Da
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 NCBI Official Full Name    C-Jun-amino-terminal kinase-interacting protein 1
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 8 interacting protein 1
 NCBI Official Symbol    MAPK8IP1 [Similar Products]
 NCBI Official Synonym Symbols   
IB1; JIP1; JIP-1; PRKM8IP
[Similar Products]
 NCBI Protein Information    C-Jun-amino-terminal kinase-interacting protein 1; IB-1; islet-brain 1; JNK-interacting protein 1; PRKM8 interacting protein; JNK MAP kinase scaffold protein 1
 UniProt Protein Name    C-Jun-amino-terminal kinase-interacting protein 1
 UniProt Synonym Protein Names   
Islet-brain 1; IB-1; JNK MAP kinase scaffold protein 1; Mitogen-activated protein kinase 8-interacting protein 1
 Protein Family    C-Jun-amino-terminal kinase-interacting protein
 UniProt Gene Name    MAPK8IP1 [Similar Products]
 UniProt Synonym Gene Names    IB1; JIP1; PRKM8IP; JIP-1; JNK-interacting protein 1; IB-1 [Similar Products]
 UniProt Entry Name    JIP1_HUMAN
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 NCBI Summary for MAPK8IP1    This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
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 UniProt Comments for MAPK8IP1    JIP1: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade. Required for JNK activation in response to excitotoxic stress. Causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and by inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly or indirectly regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: endoplasmic reticulum membrane; perinuclear region of cytoplasm; mitochondrial membrane; cytoplasm; synapse; nucleus; cytosol

Molecular Function: identical protein binding; JUN kinase binding; MAP-kinase scaffold activity; protein binding; protein kinase inhibitor activity; mitogen-activated protein kinase kinase binding; kinesin binding; mitogen-activated protein kinase kinase kinase binding

Biological Process: vesicle-mediated transport; negative regulation of JNK activity; regulation of transcription, DNA-dependent; positive regulation of signal transduction; regulation of JNK cascade; JUN phosphorylation

Disease: Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on MAPK8IP1    1. analysis of the role of JIP1 in APP transport; knockdown of JIP1 did not affect either amyloid precursor protein transport or amyloid-beta peptide production
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MAPK8IP1 elisa kitPathways associated with MAPK8IP1 elisa kit
 Reference Product  PubMed Publications
 MAPK8 elisa kit  >13 publications with MAPK8IP1 and MAPK8
 APP elisa kit  >10 publications with MAPK8IP1 and APP
 MAP2K7 elisa kit  >5 publications with MAPK8IP1 and MAP2K7
 VRK2 elisa kit  >3 publications with MAPK8IP1 and VRK2
 LRP8 elisa kit  >2 publications with MAPK8IP1 and LRP8
 MAPK10 elisa kit  >1 publications with MAPK8IP1 and MAPK10
 RELN elisa kit  >1 publications with MAPK8IP1 and RELN
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
Diseases associated with MAPK8IP1 elisa kitOrgans/Tissues associated with MAPK8IP1 elisa kit
 Disease Name  Pubmed Publications
 Death Antibodies  >22 publications with MAPK8IP1 and Death
 Brain Diseases Antibodies  >15 publications with MAPK8IP1 and Brain Diseases
 Carcinoma Antibodies  >6 publications with MAPK8IP1 and Carcinoma
 Genital Diseases, Male Antibodies  >4 publications with MAPK8IP1 and Genital Diseases, Male
 Necrosis Antibodies  >4 publications with MAPK8IP1 and Necrosis
 Prostatic Diseases Antibodies  >3 publications with MAPK8IP1 and Prostatic Diseases
 Diabetes Mellitus, Type 2 Antibodies  >3 publications with MAPK8IP1 and Diabetes Mellitus, Type 2
 Inflammation Antibodies  >2 publications with MAPK8IP1 and Inflammation
 Poisoning Antibodies  >2 publications with MAPK8IP1 and Poisoning
 Seizures Antibodies  >2 publications with MAPK8IP1 and Seizures
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with MAPK8IP1 and Brain
 Nerve Antibodies  >20 publications with MAPK8IP1 and Nerve
 Pancreas Antibodies  >11 publications with MAPK8IP1 and Pancreas
 Prostate Antibodies  >3 publications with MAPK8IP1 and Prostate
 Skin Antibodies  >3 publications with MAPK8IP1 and Skin
 Muscle Antibodies  >2 publications with MAPK8IP1 and Muscle
 Eye Antibodies  >2 publications with MAPK8IP1 and Eye
 Ovary Antibodies  >1 publications with MAPK8IP1 and Ovary
 Embryonic Tissue Antibodies  >1 publications with MAPK8IP1 and Embryonic Tissue
 Testis Antibodies  >1 publications with MAPK8IP1 and Testis
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