AAH52576.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,485 Da
NCBI Official Full Name
CTDP1 protein, partial
NCBI Official Synonym Full Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
NCBI Official Synonym Symbols
NCBI Protein Information
RNA polymerase II subunit A C-terminal domain phosphatase; serine phosphatase FCP1a; TFIIF-associating CTD phosphatase 1; CTD of POLR2A, phosphatase of, subunit 1; transcription factor IIF-associating CTD phosphatase 1
UniProt Protein Name
RNA polymerase II subunit A C-terminal domain phosphatase
UniProt Synonym Protein Names
TFIIF-associating CTD phosphatase
UniProt Synonym Gene Names
UniProt Entry Name
CTDP1_HUMAN
NCBI Summary for CTDP1
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for CTDP1
CTDP1: a phospho-serine/threonine protein phosphatase which interacts with the carboxy-terminus of transcription initiation factor TFIIF-alpha, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. Its phosphorylation increases binding to TFIIF-alpha, affecting transcription elongation. Alternative splicing results in two different isoforms.
Protein type: Transcription initiation complex; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: nucleoplasm; spindle pole; centrosome; cytoplasm; spindle; spindle midzone; midbody; actin cytoskeleton
Molecular Function: DNA-directed RNA polymerase activity; CTD phosphatase activity
Biological Process: transcription from RNA polymerase II promoter; viral reproduction; cell division; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; protein amino acid dephosphorylation; exit from mitosis
Disease: Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Research Articles on CTDP1
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Pathways associated with CTDP1 elisa kit
Diseases associated with CTDP1 elisa kit
Organs/Tissues associated with CTDP1 elisa kit
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