NP_004924.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
88,916 Da
NCBI Official Full Name
cadherin-15 preproprotein
NCBI Official Synonym Full Names
cadherin 15, type 1, M-cadherin (myotubule)
NCBI Protein Information
cadherin-15; cadherin-3; cadherin-14; muscle-cadherin
UniProt Protein Name
Cadherin-15
UniProt Synonym Protein Names
Cadherin-14; Muscle cadherin; M-cadherin
UniProt Synonym Gene Names
UniProt Entry Name
CAD15_HUMAN
NCBI Summary for CDH15
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
UniProt Comments for CDH15
CDH15: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: integral to membrane; plasma membrane; caveola; neuromuscular junction
Molecular Function: calcium ion binding
Biological Process: intercellular junction assembly and maintenance; muscle cell differentiation; positive regulation of muscle cell differentiation; homophilic cell adhesion; cell adhesion
Disease: Mental Retardation, Autosomal Dominant 3
Research Articles on CDH15
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Products associated with CDH15 elisa kit
Pathways associated with CDH15 elisa kit
Diseases associated with CDH15 elisa kit
Organs/Tissues associated with CDH15 elisa kit
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