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CDHE elisa kit :: Bovine Cadherin, Epithelial ELISA Kit

Scan QR to view Datasheet Catalog #    MBS021577 CDHE elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cadherin, Epithelial (CDHE), ELISA Kit

 Also Known As   

Bovine Cadherin, Epithelial ELISA Kit

 Product Gene Name   

CDHE elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    137215
 3D Structure    ModBase 3D Structure for P12830
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 Species Reactivity    Bovine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CDHE elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CDHE purchase    MBS021577 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cadherin, Epithelial (CDHE) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CDHE. The ELISA analytical biochemical technique of the MBS021577 kit is based on CDHE antibody-CDHE antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CDHE antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CDHE. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CDHE. It may not necessarily be applicable to this product.
 NCBI GI #    399166
 NCBI GeneID    999
 NCBI Accession #    P12830.3 [Other Products]
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 UniProt Primary Accession #    P12830 [Other Products]
 UniProt Secondary Accession #    Q13799; Q14216; Q15855; Q16194; Q4PJ14; A8K1U7 [Other Products]
 UniProt Related Accession #    P12830 [Other Products]
 Molecular Weight    97,456 Da
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 NCBI Official Full Name    Cadherin-1
 NCBI Official Synonym Full Names    cadherin 1, type 1, E-cadherin (epithelial)
 NCBI Official Symbol    CDH1 [Similar Products]
 NCBI Official Synonym Symbols   
UVO; CDHE; ECAD; LCAM; Arc-1; CD324
[Similar Products]
 NCBI Protein Information    cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial
 UniProt Protein Name    Cadherin-1
 UniProt Synonym Protein Names   
CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin
 Protein Family    Acetyl-CoA decarbonylase/synthase complex
 UniProt Gene Name    CDH1 [Similar Products]
 UniProt Synonym Gene Names    CDHE; UVO; E-cadherin [Similar Products]
 UniProt Entry Name    CADH1_HUMAN
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 NCBI Summary for CDHE    This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDHE    CDH1: a single-pass type I membrane protein, and calcium dependent cell adhesion proteins. It is a ligand for integrin alpha-E/beta-7, and it colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis. Has a potent invasive suppressor role.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: apical junction complex; internal side of plasma membrane; focal adhesion; cell surface; lateral loop; basolateral plasma membrane; extracellular region; integral to membrane; trans-Golgi network; catenin complex; actin cytoskeleton; cell-cell adherens junction; apical part of cell; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nerve terminal; cell junction; endosome; lateral plasma membrane

Molecular Function: protein domain specific binding; protein binding; gamma-catenin binding; beta-catenin binding; GTPase activating protein binding; calcium ion binding; ankyrin binding; cell adhesion molecule binding; glycoprotein binding; protein phosphatase binding

Biological Process: response to drug; intercellular junction assembly and maintenance; regulation of immune response; extracellular matrix organization and biogenesis; apoptosis; positive regulation of transcription, DNA-dependent; response to toxin; regulation of caspase activity; trophectodermal cell differentiation; regulation of water loss via skin; extracellular matrix disassembly; cell-cell adhesion; synaptogenesis; sensory perception of sound; pituitary gland development; protein metabolic process; calcium-dependent cell-cell adhesion; positive regulation of transcription factor import into nucleus; negative regulation of cell-cell adhesion; homophilic cell adhesion; neurite development; protein homooligomerization; cell structure disassembly during apoptosis; negative regulation of epithelial cell proliferation

Disease: Gastric Cancer, Hereditary Diffuse; Breast Cancer; Prostate Cancer; Ovarian Cancer; Endometrial Cancer
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 Research Articles on CDHE    1. Data indicate that up-regulation of Slug was significantly correlated with a higher tumor stage and the E- to N-cadherin switch in bladder cancer cells and tissues.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CDHE elisa kitPathways associated with CDHE elisa kit
 Reference Product  PubMed Publications
 CTNNB1 elisa kit  >157 publications with CDHE and CTNNB1
 CDC27 elisa kit  >21 publications with CDHE and CDC27
 SRC elisa kit  >11 publications with CDHE and SRC
 CTNNA1 elisa kit  >8 publications with CDHE and CTNNA1
 JUP elisa kit  >4 publications with CDHE and JUP
 CBLL1 elisa kit  >2 publications with CDHE and CBLL1
 UBC elisa kit  >1 publications with CDHE and UBC
 CTNND1 elisa kit  >1 publications with CDHE and CTNND1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
Diseases associated with CDHE elisa kitOrgans/Tissues associated with CDHE elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1009 publications with CDHE and Neoplasms
 Carcinoma Antibodies  >500 publications with CDHE and Carcinoma
 Stomach Neoplasms Antibodies  >300 publications with CDHE and Stomach Neoplasms
 Breast Neoplasms Antibodies  >240 publications with CDHE and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >157 publications with CDHE and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >137 publications with CDHE and Neoplasm Invasiveness
 Colorectal Neoplasms Antibodies  >105 publications with CDHE and Colorectal Neoplasms
 Disease Progression Antibodies  >102 publications with CDHE and Disease Progression
 Carcinoma, Squamous Cell Antibodies  >71 publications with CDHE and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >65 publications with CDHE and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >316 publications with CDHE and Stomach
 Blood Antibodies  >106 publications with CDHE and Blood
 Lung Antibodies  >97 publications with CDHE and Lung
 Lymph Node Antibodies  >88 publications with CDHE and Lymph Node
 Liver Antibodies  >76 publications with CDHE and Liver
 Brain Antibodies  >58 publications with CDHE and Brain
 Prostate Antibodies  >56 publications with CDHE and Prostate
 Embryonic Tissue Antibodies  >43 publications with CDHE and Embryonic Tissue
 Kidney Antibodies  >41 publications with CDHE and Kidney
 Bladder Antibodies  >29 publications with CDHE and Bladder
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