NP_008819.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,838 Da
NCBI Official Full Name
calmodulin
NCBI Official Synonym Full Names
calmodulin 1
NCBI Official Synonym Symbols
caM; CAMI; PHKD; CPVT4; DD132; LQT14; CALML2 [Similar Products]
NCBI Protein Information
calmodulin
UniProt Protein Name
Calmodulin
UniProt Synonym Gene Names
UniProt Entry Name
CALM_HUMAN
NCBI Summary for CAM
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for CAM
Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 14q32.11
Cellular Component: centrosome; cytoplasm; cytosol; extracellular region; nucleoplasm; nucleus; plasma membrane; sarcomere; spindle microtubule; spindle pole; vesicle
Molecular Function: calcium ion binding; inositol trisphosphate 3-kinase activity; ligand-gated ion channel activity; N-terminal myristoylation domain binding; phospholipase binding; protein binding; protein domain specific binding; protein kinase binding; protein serine/threonine kinase activator activity; Ras guanyl-nucleotide exchange factor activity; thioesterase binding; titin binding
Biological Process: detection of calcium ion; G-protein coupled receptor protein signaling pathway; glycogen catabolic process; inositol phosphate metabolic process; MAPKKK cascade; muscle contraction; platelet degranulation; positive regulation of cyclic nucleotide metabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of protein amino acid dephosphorylation; regulation of cytokinesis; regulation of heart rate; regulation of nitric-oxide synthase activity; regulation of rhodopsin mediated signaling; response to calcium ion; substantia nigra development; Wnt receptor signaling pathway, calcium modulating pathway
Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
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Products associated with CAM elisa kit
Pathways associated with CAM elisa kit
Diseases associated with CAM elisa kit
Organs/Tissues associated with CAM elisa kit
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