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CASP3 elisa kit :: Bovine Caspase-3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2608648 CASP3 elisa kit
Unit / Price
48-Strip-Wells  /  $300 +1 FREE 8GB USB
96-Strip-Wells  /  $475 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caspase-3 (CASP3), ELISA Kit

 Also Known As   

Bovine Caspase-3 ELISA Kit

 Product Gene Name   

CASP3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    U13737 mRNA
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 Species Reactivity    Bovine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CASP3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CASP3 purchase    MBS2608648 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Caspase-3 (CASP3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CASP3. The ELISA analytical biochemical technique of the MBS2608648 kit is based on CASP3 antibody-CASP3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CASP3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CASP3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CASP3. It may not necessarily be applicable to this product.
 NCBI GI #    14790119
 NCBI GeneID    836
 NCBI Accession #    NP_004337.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004346.3 [Other Products]
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 UniProt Secondary Accession #    Q96AN1; Q96KP2; A8K5M2; D3DP53 [Other Products]
 UniProt Related Accession #    P42574 [Other Products]
 Molecular Weight    31,608 Da [Similar Products]
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 NCBI Official Full Name    caspase-3 preproprotein
 NCBI Official Synonym Full Names    caspase 3
 NCBI Official Symbol    CASP3 [Similar Products]
 NCBI Official Synonym Symbols   
CPP32; SCA-1; CPP32B
[Similar Products]
 NCBI Protein Information    caspase-3
 UniProt Protein Name    Caspase-3
 UniProt Synonym Protein Names   
Apopain; Cysteine protease CPP32; CPP-32
 Protein Family    Caspase
 UniProt Gene Name    CASP3 [Similar Products]
 UniProt Synonym Gene Names    CPP32; CASP-3; CPP-32; SCA-1 [Similar Products]
 UniProt Entry Name    CASP3_HUMAN
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 NCBI Summary for CASP3    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CASP3    CASP3: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family.

Protein type: Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 4q34

Cellular Component: cytosol; nucleoplasm; nucleus; plasma membrane

Molecular Function: aspartic-type endopeptidase activity; caspase activator activity; cysteine-type endopeptidase activity; peptidase activity; protein binding

Biological Process: apoptosis; caspase activation; caspase activation via cytochrome c; cell structure disassembly during apoptosis; DNA fragmentation during apoptosis; erythrocyte differentiation; keratinocyte differentiation; negative regulation of apoptosis; nerve growth factor receptor signaling pathway; neuron differentiation; platelet formation; proteolysis; regulation of macroautophagy
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 Research Articles on CASP3    1. The aim of this study was to determine the expression of apoptotic factors Bax, Bcl-2, and Caspase-3 in lens epithelial cells (LECs) from cataracts secondary to pars plana vitrectomy with silicone oil (SO) tamponade.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CASP3 elisa kitPathways associated with CASP3 elisa kit
 Reference Product  PubMed Publications
 CASP9 elisa kit  >7284 publications with CASP3 and CASP9
 CASP8 elisa kit  >5146 publications with CASP3 and CASP8
 XIAP elisa kit  >978 publications with CASP3 and XIAP
 CASP6 elisa kit  >473 publications with CASP3 and CASP6
 PARP1 elisa kit  >424 publications with CASP3 and PARP1
 APAF1 elisa kit  >348 publications with CASP3 and APAF1
 GZMB elisa kit  >92 publications with CASP3 and GZMB
 BIRC3 elisa kit  >47 publications with CASP3 and BIRC3
 BIRC2 elisa kit  >41 publications with CASP3 and BIRC2
 DFFA elisa kit  >5 publications with CASP3 and DFFA
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
Diseases associated with CASP3 elisa kitOrgans/Tissues associated with CASP3 elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >6397 publications with CASP3 and Necrosis
 Nervous System Diseases Antibodies  >5021 publications with CASP3 and Nervous System Diseases
 Inflammation Antibodies  >3475 publications with CASP3 and Inflammation
 Reperfusion Injury Antibodies  >2235 publications with CASP3 and Reperfusion Injury
 Liver Diseases Antibodies  >2185 publications with CASP3 and Liver Diseases
 Brain Ischemia Antibodies  >1596 publications with CASP3 and Brain Ischemia
 Heart Diseases Antibodies  >1497 publications with CASP3 and Heart Diseases
 Breast Neoplasms Antibodies  >1396 publications with CASP3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1252 publications with CASP3 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >849 publications with CASP3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7382 publications with CASP3 and Brain
 Blood Antibodies  >7342 publications with CASP3 and Blood
 Liver Antibodies  >4000 publications with CASP3 and Liver
 Muscle Antibodies  >3273 publications with CASP3 and Muscle
 Vascular Antibodies  >3093 publications with CASP3 and Vascular
 Lung Antibodies  >3083 publications with CASP3 and Lung
 Heart Antibodies  >2845 publications with CASP3 and Heart
 Kidney Antibodies  >1974 publications with CASP3 and Kidney
 Bone Antibodies  >1708 publications with CASP3 and Bone
 Prostate Antibodies  >1197 publications with CASP3 and Prostate
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