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CYP11A1 elisa kit :: Bovine Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7240005 CYP11A1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1), ELISA Kit

 Also Known As   

Bovine Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) ELISA Kit

 Product Gene Name   

CYP11A1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 613743
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 Species Reactivity    Bovine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CYP11A1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CYP11A1 purchase    MBS7240005 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CYP11A1. The ELISA analytical biochemical technique of the MBS7240005 kit is based on CYP11A1 antibody-CYP11A1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CYP11A1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CYP11A1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CYP11A1. It may not necessarily be applicable to this product.
 NCBI GI #    153218646
 NCBI GeneID    1583
 NCBI Accession #    NP_000772.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000781.2 [Other Products]
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 UniProt Secondary Accession #    Q15081; Q16805; Q8N1A7; A8K8D5; B3KPU8; G3XAD7 [Other Products]
 UniProt Related Accession #    P05108 [Other Products]
 Molecular Weight    42,152 Da
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 NCBI Official Full Name    cholesterol side-chain cleavage enzyme, mitochondrial isoform a
 NCBI Official Synonym Full Names    cytochrome P450, family 11, subfamily A, polypeptide 1
 NCBI Official Symbol    CYP11A1 [Similar Products]
 NCBI Official Synonym Symbols   
CYP11A; CYPXIA1; P450SCC
[Similar Products]
 NCBI Protein Information    cholesterol side-chain cleavage enzyme, mitochondrial; steroid 20-22-lyase; cytochrome P450 11A1; cytochrome P450(scc); cytochrome P450C11A1; cholesterol 20-22 desmolase; cholesterol monooxygenase (side-chain cleaving); cytochrome P450, subfamily XIA (cholesterol side chain cleavage)
 UniProt Protein Name    Cholesterol side-chain cleavage enzyme, mitochondrial
 UniProt Synonym Protein Names   
CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)
 Protein Family    Cholesterol side-chain cleavage enzyme
 UniProt Gene Name    CYP11A1 [Similar Products]
 UniProt Synonym Gene Names    CYP11A [Similar Products]
 UniProt Entry Name    CP11A_HUMAN
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 NCBI Summary for CYP11A1    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP11A1    CYP11A1: Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR). A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia. Belongs to the cytochrome P450 family.

Protein type: Lipid Metabolism - C21-steroid hormone; Oxidoreductase; EC 1.14.15.6; Mitochondrial

Chromosomal Location of Human Ortholog: 15q23-q24

Cellular Component: mitochondrial crista; mitochondrion; mitochondrial matrix; perikaryon

Molecular Function: cholesterol monooxygenase (side-chain-cleaving) activity; iron ion binding; cholesterol binding; heme binding

Biological Process: response to alkaloid; steroid metabolic process; maternal process involved in pregnancy; dibenzo-p-dioxin metabolic process; response to insecticide; estrogen biosynthetic process; response to L-ascorbic acid; response to salt stress; response to vitamin E; Leydig cell differentiation; biphenyl metabolic process; cerebellum development; response to gamma radiation; response to corticosterone stimulus; response to drug; cholesterol metabolic process; progesterone biosynthetic process; fractalkine metabolic process; hippocampus development; phthalate metabolic process; mating behavior; vitamin D metabolic process; Schwann cell differentiation; response to genistein; response to hydrogen peroxide; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; sterol metabolic process; granulosa cell differentiation; phenol metabolic process

Disease: Adrenal Insufficiency, Congenital, With 46,xy Sex Reversal, Partial Or Complete
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 Research Articles on CYP11A1    1. the CYP11A1, CYP17A1, HSD3B2, SRD5A2, and HSD17B6 mRNA levels in metastases were significantly lower.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CYP11A1 elisa kitPathways associated with CYP11A1 elisa kit
 Reference Product  PubMed Publications
 CYP17A1 elisa kit  >454 publications with CYP11A1 and CYP17A1
 HSD3B1 elisa kit  >57 publications with CYP11A1 and HSD3B1
 HSD3B2 elisa kit  >38 publications with CYP11A1 and HSD3B2
 STS elisa kit  >5 publications with CYP11A1 and STS
 FDX1 elisa kit  >5 publications with CYP11A1 and FDX1
 CYP7B1 elisa kit  >3 publications with CYP11A1 and CYP7B1
 SULT2B1 elisa kit  >1 publications with CYP11A1 and SULT2B1
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
Diseases associated with CYP11A1 elisa kitOrgans/Tissues associated with CYP11A1 elisa kit
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >98 publications with CYP11A1 and Hyperplasia
 Congenital Abnormalities Antibodies  >84 publications with CYP11A1 and Congenital Abnormalities
 Disorders of Sex Development Antibodies  >83 publications with CYP11A1 and Disorders of Sex Development
 Genital Diseases, Male Antibodies  >68 publications with CYP11A1 and Genital Diseases, Male
 Adrenal Insufficiency Antibodies  >54 publications with CYP11A1 and Adrenal Insufficiency
 Testicular Diseases Antibodies  >50 publications with CYP11A1 and Testicular Diseases
 Hypertension Antibodies  >29 publications with CYP11A1 and Hypertension
 Necrosis Antibodies  >23 publications with CYP11A1 and Necrosis
 Nervous System Diseases Antibodies  >21 publications with CYP11A1 and Nervous System Diseases
 Infertility, Male Antibodies  >19 publications with CYP11A1 and Infertility, Male
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >731 publications with CYP11A1 and Adrenal Gland
 Ovary Antibodies  >716 publications with CYP11A1 and Ovary
 Testis Antibodies  >436 publications with CYP11A1 and Testis
 Placenta Antibodies  >193 publications with CYP11A1 and Placenta
 Brain Antibodies  >179 publications with CYP11A1 and Brain
 Liver Antibodies  >134 publications with CYP11A1 and Liver
 Embryonic Tissue Antibodies  >90 publications with CYP11A1 and Embryonic Tissue
 Kidney Antibodies  >62 publications with CYP11A1 and Kidney
 Heart Antibodies  >26 publications with CYP11A1 and Heart
 Uterus Antibodies  >23 publications with CYP11A1 and Uterus
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