NP_072170.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,914 Da
NCBI Official Full Name
chorionic somatomammotropin hormone 2 isoform 2
NCBI Official Synonym Full Names
chorionic somatomammotropin hormone 2
NCBI Protein Information
chorionic somatomammotropin hormone 2; lactogen; choriomammotropin; placental lactogen; chorionic somatomammotropin B
UniProt Protein Name
Chorionic somatomammotropin hormone 2
UniProt Synonym Protein Names
Lactogen; Placental lactogen; PL
UniProt Synonym Gene Names
UniProt Entry Name
CSH2_HUMAN
NCBI Summary for CSH2
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]
UniProt Comments for CSH2
CSH1: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. Belongs to the somatotropin/prolactin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q24.2
Cellular Component: extracellular region
Molecular Function: metal ion binding; hormone activity
Research Articles on CSH2
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Pathways associated with CSH2 elisa kit
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