NP_003661.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
class E basic helix-loop-helix protein 40
NCBI Official Synonym Full Names
basic helix-loop-helix family, member e40
NCBI Official Synonym Symbols
DEC1; HLHB2; BHLHB2; STRA13; Stra14; SHARP-2 [Similar Products]
NCBI Protein Information
class E basic helix-loop-helix protein 40; class B basic helix-loop-helix protein 2; differentially expressed in chondrocytes 1; stimulated by retinoic acid gene 13 protein; enhancer-of-split and hairy-related protein 2; differentially expressed in chondrocytes protein 1; differentiated embryo chondrocyte expressed gene 1; basic helix-loop-helix domain containing, class B, 2
UniProt Protein Name
Class E basic helix-loop-helix protein 40
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 2; bHLHb2; Differentially expressed in chondrocytes protein 1; DEC1; Enhancer-of-split and hairy-related protein 2; SHARP-2; Stimulated by retinoic acid gene 13 protein
UniProt Synonym Gene Names
UniProt Entry Name
BHE40_HUMAN
NCBI Summary for BHLHE40
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]
UniProt Comments for BHLHE40
BHLHB2: May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway.
Protein type: Nucleolus; Transcription regulation
Chromosomal Location of Human Ortholog: 3p26
Cellular Component: nucleoplasm; Golgi apparatus; nucleolus; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein domain specific binding; protein binding; MRF binding; protein homodimerization activity; protein heterodimerization activity; bHLH transcription factor binding; transcription corepressor activity; transcription factor activity
Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; entrainment of circadian clock by photoperiod
Research Articles on BHLHE40
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Pathways associated with BHLHE40 elisa kit
Diseases associated with BHLHE40 elisa kit
Organs/Tissues associated with BHLHE40 elisa kit
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