NP_056507.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
199,171 Da
NCBI Official Full Name
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
NCBI Official Synonym Full Names
C3 and PZP like, alpha-2-macroglobulin domain containing 8
NCBI Official Synonym Symbols
NCBI Protein Information
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
UniProt Protein Name
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
UniProt Synonym Gene Names
UniProt Entry Name
CPMD8_HUMAN
NCBI Summary for C3
CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008]
UniProt Comments for C3
CPAMD8: Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Up-regulated by IL1B/interleukin-1 beta and IL6/interleukin-6. Interacts with heparin. 2 isoforms of the human protein are produced by alternative splicing
Chromosomal Location of Human Ortholog: 19p13.11
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Organs/Tissues associated with C3 elisa kit
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