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C5B elisa kit :: Bovine Complement Component 5B ELISA Kit

Scan QR to view Datasheet Catalog #    MBS008530 C5B elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Complement Component 5B (C5B), ELISA Kit

 Also Known As   

Bovine Complement Component 5B ELISA Kit

 Product Gene Name   

C5B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    120900
 3D Structure    ModBase 3D Structure for P01031
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 Species Reactivity    Bovine
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Bovine body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich (Quantitative)
 Detection Range    15.6 ng/ml - 500 ng/ml.
 Sensitivity    2.0 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of C5B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for C5B purchase    MBS008530 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Complement Component 5B (C5B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6 ng/ml - 500 ng/ml in biological research samples containing C5B, with an estimated sensitivity of 2.0 ng/ml. The ELISA analytical biochemical technique of the MBS008530 kit is based on C5B antibody-C5B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C5B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, C5B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Bovine body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for C5B elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of C5B (hereafter termed "analyte") in undiluted original Bovine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS008530. Click to request current manual
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NCBI/Uniprot data below describe general gene information for C5B. It may not necessarily be applicable to this product.
 NCBI GI #    38016947
 NCBI GeneID    727
 NCBI Accession #    NP_001726.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001735.2 [Other Products]
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 UniProt Primary Accession #    P01031 [Other Products]
 UniProt Secondary Accession #    Q14CJ0; Q27I61 [Other Products]
 UniProt Related Accession #    P01031 [Other Products]
 Molecular Weight    188,305 Da
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 NCBI Official Full Name    complement C5 preproprotein
 NCBI Official Synonym Full Names    complement component 5
 NCBI Official Symbol    C5 [Similar Products]
 NCBI Official Synonym Symbols   
C5D; C5a; C5b; ECLZB; CPAMD4
[Similar Products]
 NCBI Protein Information    complement C5; prepro-C5; C5a anaphylatoxin; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
 UniProt Protein Name    Complement C5
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
 UniProt Gene Name    C5 [Similar Products]
 UniProt Synonym Gene Names    CPAMD4 [Similar Products]
 UniProt Entry Name    CO5_HUMAN
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 NCBI Summary for C5B    The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for C5B    C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q33-q34

Cellular Component: membrane attack complex; extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; endopeptidase inhibitor activity; C5a anaphylatoxin chemotactic receptor binding; receptor binding

Biological Process: positive regulation of chemotaxis; activation of MAPK activity; in utero embryonic development; cytolysis; complement activation, alternative pathway; chemotaxis; glucose homeostasis; leukocyte migration during inflammatory response; complement activation; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of complement activation; innate immune response; response to stress; inflammatory response; negative regulation of dopamine secretion; complement activation, classical pathway

Disease: Complement Component 5 Deficiency; Eculizumab, Poor Response To
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 Research Articles on C5B    1. C5a, but not C5a-des Arg, was able to induce further heteromer formation between complement C5a receptors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with C5B elisa kitPathways associated with C5B elisa kit
 Reference Product  PubMed Publications
 C5AR1 elisa kit  >10 publications with C5B and C5AR1
 C8A elisa kit  >5 publications with C5B and C8A
 GPR77 elisa kit  >4 publications with C5B and GPR77
 C8B elisa kit  >3 publications with C5B and C8B
 NMU elisa kit  >1 publications with C5B and NMU
 C3AR1 elisa kit  >1 publications with C5B and C3AR1
 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with C5B elisa kitOrgans/Tissues associated with C5B elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2155 publications with C5B and Nervous System Diseases
 Inflammation Antibodies  >691 publications with C5B and Inflammation
 Cardiovascular Diseases Antibodies  >628 publications with C5B and Cardiovascular Diseases
 Vascular Diseases Antibodies  >613 publications with C5B and Vascular Diseases
 Complement component 5 deficiency Antibodies  >592 publications with C5B and Complement component 5 deficiency
 Autoimmune Diseases Antibodies  >456 publications with C5B and Autoimmune Diseases
 Hemolysis Antibodies  >444 publications with C5B and Hemolysis
 Kidney Diseases Antibodies  >406 publications with C5B and Kidney Diseases
 Necrosis Antibodies  >219 publications with C5B and Necrosis
 Anemia Antibodies  >211 publications with C5B and Anemia
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2060 publications with C5B and Bone
 Muscle Antibodies  >1201 publications with C5B and Muscle
 Brain Antibodies  >726 publications with C5B and Brain
 Lung Antibodies  >459 publications with C5B and Lung
 Kidney Antibodies  >457 publications with C5B and Kidney
 Liver Antibodies  >430 publications with C5B and Liver
 Spleen Antibodies  >166 publications with C5B and Spleen
 Bone Marrow Antibodies  >120 publications with C5B and Bone Marrow
 Intestine Antibodies  >116 publications with C5B and Intestine
 Eye Antibodies  >97 publications with C5B and Eye
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