NP_005198.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,777 Da
NCBI Official Full Name
crk-like protein
NCBI Official Synonym Full Names
v-crk avian sarcoma virus CT10 oncogene homolog-like
NCBI Protein Information
crk-like protein
UniProt Protein Name
Crk-like protein
UniProt Entry Name
CRKL_HUMAN
NCBI Summary for CRKL
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
UniProt Comments for CRKL
CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytosol; endosome
Molecular Function: signal transducer activity; protein binding; SH3/SH2 adaptor activity
Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; nerve growth factor receptor signaling pathway; activation of MAPKK activity; thymus development; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
Research Articles on CRKL
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Products associated with CRKL elisa kit
Pathways associated with CRKL elisa kit
Diseases associated with CRKL elisa kit
Disease Name |
Pubmed Publications |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies |
>87 publications with CRKL and Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Leukemia, Myeloid, Acute Antibodies |
>13 publications with CRKL and Leukemia, Myeloid, Acute |
Disease Models, Animal Antibodies |
>12 publications with CRKL and Disease Models, Animal |
Craniofacial Abnormalities Antibodies |
>12 publications with CRKL and Craniofacial Abnormalities |
Lung Neoplasms Antibodies |
>12 publications with CRKL and Lung Neoplasms |
DiGeorge Syndrome Antibodies |
>11 publications with CRKL and DiGeorge Syndrome |
Breast Neoplasms Antibodies |
>7 publications with CRKL and Breast Neoplasms |
Neoplasms, Experimental Antibodies |
>7 publications with CRKL and Neoplasms, Experimental |
Inflammation Antibodies |
>5 publications with CRKL and Inflammation |
Skin Diseases Antibodies |
>5 publications with CRKL and Skin Diseases |
Organs/Tissues associated with CRKL elisa kit
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