NP_445784.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
398,987 Da
NCBI Official Full Name
cubilin
NCBI Official Synonym Full Names
cubilin (intrinsic factor-cobalamin receptor)
NCBI Protein Information
cubilin; 460 kDa receptor; glycoprotein 280; intrinsic factor-cobalamin receptor; intrinsic factor-vitamin B12 receptor
UniProt Protein Name
Cubilin
UniProt Synonym Protein Names
460 kDa receptor; Glycoprotein 280; gp280; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor
UniProt Synonym Gene Names
UniProt Entry Name
CUBN_RAT
NCBI Summary for CUBN
receptor for intrinsic factor (IF)-cobalamin; involved in vitamin B12 uptake (cyanocobalamin) [RGD, Feb 2006]
UniProt Comments for CUBN
CUBN: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Defects in CUBN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1); also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected.
Cellular Component: Golgi apparatus; lysosomal lumen; protein complex; brush border membrane; lysosomal membrane; endoplasmic reticulum; coated pit; membrane; apical part of cell; endocytic vesicle; cytoplasm; apical plasma membrane; endosome membrane; endosome; brush border
Molecular Function: identical protein binding; protein homodimerization activity; hemoglobin binding; cobalamin transporter activity; calcium ion binding; receptor activity; cobalamin binding
Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; vitamin metabolic process; in utero embryonic development; lipoprotein transport; cobalamin transport; hemoglobin import; response to nutrient
Research Articles on CUBN
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Products associated with CUBN elisa kit
Pathways associated with CUBN elisa kit
Diseases associated with CUBN elisa kit
Organs/Tissues associated with CUBN elisa kit
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