NP_001161842.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
199,750 Da
NCBI Official Full Name
cullin-7 isoform 1
NCBI Official Synonym Full Names
cullin 7
NCBI Protein Information
cullin-7; CUL-7
UniProt Protein Name
Cullin-7
UniProt Synonym Gene Names
UniProt Entry Name
CUL7_HUMAN
NCBI Summary for CUL7
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
UniProt Comments for CUL7
CUL7: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. Belongs to the cullin family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: nucleoplasm; Golgi apparatus; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: ubiquitin-dependent protein catabolic process; viral reproduction; unfolded protein response; protein ubiquitination; positive regulation of dendrite morphogenesis; microtubule cytoskeleton organization and biogenesis; proteolysis; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; cytokinesis after mitosis; regulation of mitosis; epithelial to mesenchymal transition; vasculogenesis; Golgi organization and biogenesis; placenta development
Disease: Three M Syndrome 1
Research Articles on CUL7
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Products associated with CUL7 elisa kit
Pathways associated with CUL7 elisa kit
Diseases associated with CUL7 elisa kit
Organs/Tissues associated with CUL7 elisa kit
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